Publications by authors named "Taylor B Engle"
Porcine circovirus 2 (PCV2) is a circular single-stranded DNA virus responsible for a group of diseases collectively known as PCV2 Associated Diseases (PCVAD). Variation in the incidence and severity of PCVAD exists between pigs suggesting a host genetic component involved in pathogenesis. A large-scale genome-wide association study of experimentally infected pigs (n = 974), provided evidence of a host genetic role in PCV2 viremia, immune response and growth during challenge.
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- Porcine circovirus 2 (PCV2) causes serious diseases in pigs, known as PCVAD, which affect their health and production efficiency.
- This study evaluated the differences in viral replication, immune responses, and growth rates among 974 pigs from various crossbred lines after they were experimentally infected with a specific strain of PCV2b.
- Results indicated varying levels of viremia (the presence of the virus in the blood) and immune response, with a significant negative correlation between high viral loads and average daily gain (ADG), highlighting the detrimental impact of the virus on pig growth.
- Understanding these variations could improve insights into swine immunity and the factors influencing PCVAD development.