Publications by authors named "Tayla L McCloud"
Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults.
Cochrane Database Syst Rev
September 2015
Background: There is emerging evidence that glutamatergic system dysfunction might play an important role in the pathophysiology of bipolar depression. This review focuses on the use of glutamate receptor modulators for depression in bipolar disorder.
Objectives: 1.
Ketamine and other glutamate receptor modulators for depression in adults.
Cochrane Database Syst Rev
September 2015
Background: Considering the ample evidence of involvement of the glutamate system in the pathophysiology of depression, pre-clinical and clinical studies have been conducted to assess the antidepressant efficacy of glutamate inhibition, and glutamate receptor modulators in particular. This review focuses on the use of glutamate receptor modulators in unipolar depression.
Objectives: To assess the effects - and review the acceptability - of ketamine and other glutamate receptor modulators in comparison to placebo (or saline placebo), other pharmacologically active agents, or electroconvulsive therapy (ECT) in alleviating the acute symptoms of depression in people with unipolar major depressive disorder.