Publications by authors named "Tayebeh Ranjbarnejad"
Article Synopsis
- Celiac disease (CeD) is an autoimmune disorder linked to gluten consumption, with most affected individuals having specific genetic markers (HLA-DQ2 or -DQ8) that suggest a higher risk among their first-degree relatives (FDRs), despite a low CeD prevalence rate of 7.5% in this group.
- To investigate this low prevalence, researchers analyzed intestinal biopsy data from CeD patients, their FDRs, and a control group, creating a protein-protein interaction network to understand gene expression differences.
- The study found notable differences in gene activity between CeD patients and FDRs, particularly in genes related to the cell cycle, suggesting that specific regulatory pathways may be targeted for future treatments or
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions.
View Article and Find Full Text PDFBackground: A high expression of prostaglandin E2 (PGE2) is found in colorectal cancer. Therefore, blocking of PGE2 generation has been identified as a promising approach for anticancer therapy. Sulforaphane (SFN), an isothiocyanate derived from glucosinolate, is used as the antioxidant and anticancer agents.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) is the most common cancer. A proper method to reduce mortality of CRC is chemoprevention to prevent initiation and promotion of intestinal tumorgenesis. One of the promising and developing chemopreventive agents is natural compounds found in plants.
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