Publications by authors named "Tayebeh Akbari"
Spinal cord injury (SCI) leaves a temporary or enduring motor, sensory, and autonomic function loss, significantly impacting the patient's quality of life. Given their biocompatibility, bioactivity, and tunable attributes, three-dimensional scaffolds frequently employ carbohydrates to facilitate spinal cord regeneration. These scaffolds have also been engineered to be novel local delivery platforms that present distinct advantages in the targeted transportation of drug candidates to the damaged spinal cord, ensuring the right dosage and duration of administration.
View Article and Find Full Text PDFDevelopment of an ideal wound dressing with effective function for healing various types of wounds is the ultimate desire of the researchers. Natural-based compounds such as polysaccharides and phytochemicals offer useful properties making them perfect candidates for wound management. Polysaccharides-based hydrogels with an interconnected three-dimensional network, and desired properties have great potential as a carrier for delivery of different herbal extracts for oral and topical applications.
View Article and Find Full Text PDFArticle Synopsis
- Researchers created a series of coumarin-pyridine compounds as potential multi-functional drugs for Alzheimer's disease (AD) treatment.
- These compounds demonstrated strong inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with some outperforming the standard drug donepezil.
- The most effective compound not only inhibited key enzymes but also protected nerve cells from toxic effects and reduced harmful protein aggregation, indicating it could be a promising candidate for AD therapy.
Article Synopsis
- A new series of coumarin derivatives linked to benzyl triazole was synthesized and tested for their effectiveness against enzymes related to Alzheimer's disease, specifically 15-lipoxygenase and cholinesterases.
- While most of these compounds showed only weak to moderate effects, some standouts exhibited strong neuroprotective properties, outperforming the standard drug quercetin in cell models.
- Further studies, including docking and kinetic analysis, indicated that the top-performing compounds could be promising candidates for future development in treating Alzheimer's disease, due to their solid inhibition of targeted enzymes and prevention of amyloid aggregation.
Carnosine-graphene oxide conjugates decorated with hydroxyapatite as promising nanocarrier for ICG loading with enhanced antibacterial effects in photodynamic therapy against Streptococcus mutans.
J Photochem Photobiol B
April 2018
Antimicrobial photodynamic therapy (aPDT) has been emerged as a noninvasive strategy to remove bacterial contaminants such as S. mutans from the tooth surface. Photosensitizer (PS), like indocyanine green (ICG), plays a key role in this technique which mainly suffers from the poor stability and concentration-dependent aggregation.
View Article and Find Full Text PDFBackground: Recently developed photodynamic therapy (PDT) has gained attention for achieving effective root canal disinfection. Using an optimized nontoxic photosensitizer (PS), such as indocyanine green (ICG), is an imperative part of this technique. Therefore, the objective of the current study was to improve ICG photodynamic properties through incorporation of ICG into nano-graphene oxide (NGO) in order to produce NGO-ICG as a new PS and also to assess the antimicrobial effects of NGO-ICG against Enterococcus faecalis after photodynamic therapy.
View Article and Find Full Text PDF