Publications by authors named "Tavis Abrahamsen"
Article Synopsis
- Alternating hemiplegia of childhood is a rare neurodevelopmental disorder linked to genetic mutations, showing potential disease progression despite limited systematic studies.* -
- A study involving 42 US patients found that as patients age, there is a mild worsening in non-paroxysmal disability scores, with early-life disability scores predicting later outcomes.* -
- Similar findings were observed in a French cohort and in a mouse model, indicating that age is a significant factor in the progression of the disorder.*
Quantitative MRI is increasingly being used as a biomarker in neurological disorders. Cerebellar atrophy occurs in some Alternating Hemiplegia of Childhood (AHC) patients. However, it is not known if cerebellar atrophy can be a potential biomarker in AHC or if quantitative MRI is a reliable method to address this question.
View Article and Find Full Text PDFAim: To evaluate presence and severity of social impairments in alternating hemiplegia of childhood (AHC) and determine factors that are associated with social impairments.
Method: This was a retrospective analysis of 34 consecutive patients with AHC (19 females, 15 males; mean age: 9y 7mo, SD 8y 2mo, range 2y 7mo-40y), evaluated with the Social Responsiveness Scale, Second Edition (SRS-2).
Results: SRS-2 scores, indicating level of social impairment, were higher than population means (75, SD 14 vs 50, SD 10, p<0.