Comparison of inflammatory mediator cytokine responses to inactivated virus platform COVID-19 vaccines between elderly and young adult populations.

The coronavirus disease 2019 (COVID-19) pandemic has encouraged global vaccine research, yet vaccine effectiveness in the elderly remains a concern due to immunosenescence. The aim of this study was to compare the cytokine response elicited by an inactivated virus-based COVID-19 vaccine between elderly and young adults, focusing on key cytokines involved in cellular and humoral immunity: tumor necrosis factor-alpha (TNF-α), interleukin (IL)-2, IL-6, IL-10, and interferon-gamma (IFN-γ). A cross-sectional study was conducted in the Jakarta-Bogor region of Indonesia from January 2023 to December 2023.

Thyroid Hemiagenesis: An Incidental Discovery during Treatment for Papillary Thyroid Carcinoma.

Thyroid hemiagenesis (THA) is a rare congenital abnormality in which one of the thyroid lobes fails to develop normally. The prevalence rates range from 0.02% to 0.

Alginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity.

The synergistic bioactive effect of polyphenols can enhance the development of functional foods to prevent chronic diseases such as cancer. Curcumin and quercetin have been shown to possess anticancer properties. The combination of curcumin and quercetin has been shown to provide synergistic effects against cancer cell proliferation.

How to Engage Men in Preconception Health?: A Scoping Review.

Background: Men's engagement in maternal and child health care in the preconception health forum is essential because it allows primary prevention of maternal and infant mortality and morbidity. This review aimed to identify strategies to engage men in preconception health.

Materials And Methods: This scoping review was conducted from August to September 2022.

Computational fluid particle dynamics modeling of tangential flow filtration in perfusion cell culture.

Membrane fouling is a common and complex challenge with cell culture perfusion process in biopharmaceutical manufacturing that can have detrimental effects on the process performance. In this study, we evaluated a method to calculate the hollow fiber membrane resistance at different time points for water and supernatant. In addition, the number of subvisible particles of < 200 nm.

Enhancing gender sensitivity in transgender and gender-diverse patient communication.

This article examines the communication preferences of transgender and genderdiverse individuals in the health system context. Findings suggest the importance of gender sensitivity and confident communication styles in improving patient experience. The article recommends case-based training to understand the dynamics of intersectionality and the development of communication aids to improve health literacy.

Comparison of the effects of in-person and internet-delivered mindfulness-based stress reduction on the burden of psychosomatic symptoms in nurses.

Introduction: There is some evidence comparing the efficacy of telehealth to in-person mental health care, but there is limited research specifically comparing these modalities in nurses. The study aimed to compare the effects of Mindfulness-based Stress Reduction (MBSR) and Internet-delivered Mindfulness-based Stress Reduction (iMBSR) on burden of psychosomatic symptoms of nurses working at Al-Alhamzeh general hospital, Aldiwaniyeh, Iraq.

Methods: The study was a semi-experiment study with a pre-posttest design on 72 registered nurses.

Tradeoffs among yield, cadmium bioavailability, nitrous oxide emission and bacterial community stability: Effects of iron-modified woody peat and nitrification inhibitors on soil-vegetable systems.

Cadmium (Cd) pollution leads to soil degradation, decreases crop yield and affects human health through the food chain. Iron-modified woody peat (IMP) is an organic passivation material that significantly affects the migration of heavy metals in soil. Nitrification inhibitors are widely used to reduce greenhouse gas emissions.

Chitosan adorned with ZIF-67 on ZIF-8 biocomposite: A potential LED visible light-assisted photocatalyst for wastewater decontamination.

The current investigation has utilized a simple and constructive stratified method to synthesize a binary (Cs/Z-8: chitosan (Cs) and zeolitic imidazolate framework-8 (Z-8)) and ternary Cs/Z-8/Z-67 (Z-67: ZIF-67) biocomposites at room temperature. A certain amount of Cs/Z-8 (0.05, 0.

MicroRNA-mediated regulation of Ferroptosis: Implications for disease pathogenesis and therapeutic interventions.

Ferroptosis, a form of iron-dependent regulated cell death, is characterized by the accumulation of lipid peroxides and distinctive morphological features. Moreover, the reduction of intracellular antioxidant enzyme expression or activity, specifically glutathione peroxidase 4 (GPX4) results in activation of the endogenous pathway of ferroptosis. In this review, we aimed to explore the intricate interplay between microRNAs (miRNAs) and ferroptosis, shedding light on its implications in various disease pathologies.

Intrapulmonary cavitating solitary fibrous tumor: A rare case report.

Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that affects most commonly in the sixth or seventh decade of life. They account for less than 2% of all soft tissue tumors. In the thoracic region, it primarily appears in the pleura and rarely in the intrapulmonary.

Evaluating neurosurgical society award recipients: Realising inclusivity in neurosurgical awards.

This article evaluates disparities in neurosurgical awards, focusing on the underrepresentation of women and racial minorities. It underscores the need for transparent award selection processes and diverse judging panels to foster inclusivity. The article also highlights the importance of mentorship programs in addressing systemic biases.

Chronic pain among primary fentanyl users: The concept of self-medication.

Background: Chronic pain is among the leading causes of disability worldwide, of which only a small percentage of patients receive adequate treatment for. Non-prescribed opioid analgesics are commonly sought out in effort to alleviate unrelieved pain. This study assesses the prevalence and correlates of chronic pain among primary fentanyl users.

Transformative artificial intelligence in gastric cancer: Advancements in diagnostic techniques.

Gastric cancer represents a significant global health challenge with elevated incidence and mortality rates, highlighting the need for advancements in diagnostic and therapeutic strategies. This review paper addresses the critical need for a thorough synthesis of the role of artificial intelligence (AI) in the management of gastric cancer. It provides an in-depth analysis of current AI applications, focusing on their contributions to early diagnosis, treatment planning, and outcome prediction.

Hospital Managers' Decision-Making Puzzle.

Background: Decision-making is choosing one option from among different options. Most decision-making models were developed in the general industry. Specific decision-making models are needed due to the special nature of the hospital and its services.

Segmentation of choroidal area in optical coherence tomography images using a transfer learning-based conventional neural network: a focus on diabetic retinopathy and a literature review.

Background: This study aimed to evaluate the effectiveness of DeepLabv3+with Squeeze-and-Excitation (DeepLabv3+SE) architectures for segmenting the choroid in optical coherence tomography (OCT) images of patients with diabetic retinopathy.

Methods: A total of 300 B-scans were selected from 21 patients with mild to moderate diabetic retinopathy. Six DeepLabv3+SE variants, each utilizing a different pre-trained convolutional neural network (CNN) for feature extraction, were compared.

Chlamydomonas sp. extract meliorates the growth and physiological responses of 'Camarosa' strawberry (Fragaria × ananassa Duch) under salinity stress.

Microalgae like Chlamydomonas are beneficial organisms employed as biological stimulants to improve plants' growth, fruit quality, and stress tolerance. In the current study, the effects of Chlamydomonas sp. foliar spraying (0, 20, and 40 ml L) were assayed on Camarosa strawberry plants under salinity stress (0, 40, and 80 mM NaCl).