Pregnancy Among Women Receiving Chronic Dialysis in France (2006-2020).

Introduction: In women receiving chronic dialysis, fertility is impaired. The objectives of this study were to estimate the incidence rate of pregnancies among women of childbearing age (15-50 years) receiving chronic dialysis from 2006 to 2020 in France, to describe the pregnancy outcomes and renal management during pregnancy.

Methods: This national observational, retrospective study was based on data from the French REIN registry matched with the National Health Data System.

Dermal Regeneration Template in the Management and Reconstruction of Burn Injuries and Complex Wounds: A Review.

Background: Dermal scaffolds have created a paradigm shift for burn and wound management by providing improved healing and less scarring, while improving cosmesis and functionality. Dermal regeneration template (DRT) is a bilayer membrane for dermal regeneration developed by Yannas and Burke in the 1980s. The aim of this review is to summarize clinical evidence for dermal scaffolds focusing on DRT for the management and reconstruction of burn injuries and complex wounds.

Mesenchymal Stem Cells and Regenerative Therapy with Bilateral Gracilis Flaps for Perineal Reconstruction of a Wound Infection in the Setting of Anal Squamous Cell Carcinoma.

Many patients are affected by HIV/AIDS, and these conditions are highly prevalent worldwide. Patients with HIV/AIDS can experience debilitating wound infections that often require flap reconstruction and become challenging for surgeons to treat. In the past 5 years, mesenchymal stem cells have been tested and used as regenerative therapy to promote the growth of tissues throughout the body because of their ability to successfully promote cellular mitogenesis.

Integra® Dermal Regeneration Template: From Design to Clinical Use.

Integra Dermal Regeneration Template (IDRT, Integra LifeSciences, Princeton, NJ, USA) is a bilayer membrane developed, by Yannas and Burke in the 1980s, to fulfill the unmet need of surgeons having a readily available off-the-shelf dermal regeneration method. IDRT is composed of a sheet of porous cross-linked type I collagen and glycosaminoglycans, with a semi-permeable silicone sheet cover. IDRT is bio-engineered, from adult bovine Achilles tendons and chondroitin-6-sulfate derived from shark cartilage, in a multi-step process involving cross-linking using glutaraldehyde.

Use of collagen-glycosaminoglycan silicone bilayer matrix for closure of post-Mohs micrographic surgery defects on the nose: a 5-case series.

Introduction: The use of dermal matrices has shown to be reliable and less invasive than skin grafts or skin flaps for wound management. This case series reports the clinical outcomes of 5 patients with defects on the nose post-MMS managed using collagen-glycosaminoglycan silicone bilayer matrix.

Materials And Methods: Patient 1 had a BCC of the left nasal lateral sidewall, patient 2 had a BCC of the right nasal ala, patient 3 had a BCC of the nasal dorsum, patient 4 had a BCC of the left medial canthus, and patient 5 had a BCC of the left alar lobule of the nose.

Serial application of meshed collagen-chondroitin silicone bilayer matrix to obtain full coverage over bone and tendon in challenging situations and medically compromised patients: a small case series.

Introduction: Soft tissue defects in medically compromised patients present significant challenges to the reconstructive surgeon, particularly when vital structures are exposed. This case series reports clinical outcomes of 5 adult patients with challenging medical problems whose wounds were managed using a meshed collagen-chondroitin silicone bilayer matrix to obtain coverage over bone and tendon.

Materials And Methods: Patient 1 had significant degloving of the scalp.

Specificities of Meningitis and Meningo-Encephalitis After Kidney Transplantation: A French Retrospective Cohort Study.

Kidney transplant recipients develop atypical infections in their epidemiology, presentation and outcome. Among these, meningitis and meningoencephalitis require urgent and adapted anti-infectious therapy, but published data is scarce in KTRs. The aim of this study was to describe their epidemiology, presentation and outcome, in order to improve their diagnostic and management.

Negative pressure wound therapy on complex extremity wounds requiring coverage with a meshed bilayer wound matrix: a retrospective analysis.

Objective: The treatment of complex extremity wounds is technically challenging. In this 5-year retrospective review, we compared the use of Integra Meshed Bilayer Wound Matrix (IMBWM; Integra LifeSciences, US) followed by a split-thickness skin graft (STSG) combined with negative pressure wound therapy (NPWT) versus IMBWM followed by STSG alone for the management of these wounds.

Method: Data from patients undergoing management using IMBWM for a complex extremity wound coverage were collected.

Integra Dermal Regeneration Template in reconstructive surgery for cutaneous tumours: a two-year retrospective review.

Objective: Integra Dermal Regeneration Template (IDRT) (Integra LifeSciences, US) is a bioengineered dermal matrix that has been widely used in burn reconstruction since its first description. However, little is reported on its use in oncologic dermatological defects. Our objective was to evaluate reconstruction using IDRT on cutaneous tumour defects.

Single-stage extremity reconstruction through the use of dermal matrices: the power of Integra bilayer wound matrix in the face of medical comorbidities, patient preference and non-compliance.

We report 4 cases of extremity reconstruction using Bilayer Wound Matrix with plan to perform two-stage procedures. Patient preference or non-compliance led to single-stage reconstruction with wound re-epithelialization. In this setting, dermal matrices may be used as single-stage stand alone wound reconstruction procedures, even in patients with comorbid conditions.

Strategies for extremity reconstruction with exposed bones and tendons using acellular dermal matrices: concept of sequential vascularization.

We report 3 cases of patients treated with Bilayer Wound Matrix over exposed structures. In all patients, dermal matrices revascularization occurred sequentially over the course of 6-12 weeks, leading to successful wound closure. Acellular dermal matrices allow more difficult areas with poor vascularity to be covered from the 'inside-out'.

Physiological Synchrony of the Broad Bean Weevil, Boh., to the Host Plant Phenology, L.

The aims of the study were to understand the physiological and phenological relationship between and in the perspective of IPM strategies. , an important food resource for humans and livestock is the main host plant of . Adults feed on the pollen, females lay eggs on pods, and larvae develop into the seeds.

Innovative Curative Treatment of Beta Thalassemia: Cost-Efficacy Analysis of Gene Therapy Versus Allogenic Hematopoietic Stem-Cell Transplantation.

Seventy-five percent of patients with beta thalassemia (β-thalassemia) do not have human leukocyte antigen-matched siblings and until recently had no access to a curative treatment. Gene therapy is a promising treatment that can be proposed to these patients. This study estimates its cost and efficacy.

Response of insect relative growth rate to temperature and host-plant phenology: estimation and validation from field data.

Between 1975 to 2011, aphid Relative Growth Rates (RGR) were modelled as a function of mean outdoor temperature and host plant phenology. The model was applied to the grain aphid Sitobion avenae using data on aphid counts in winter wheat at two different climate regions in France (oceanic climate, Rennes (western France); continental climate, Paris). Mean observed aphid RGR was higher in Paris compared to the Rennes region.

Changes in insulin therapy regimens over 10 yr in children and adolescents with type 1 diabetes attending diabetes camps.

Objective: To describe the changes in insulin therapy regimens of children and adolescents with type 1 diabetes over 10 yr and their correlation with hemoglobin A1c (HbA1c).

Research Design And Methods: The study included 7206 children and adolescents (age 12.8 ± 2.

Hospital burden of vertebral fractures in France: influence of vertebroplasty.

Unlabelled: We described the whole population of patients hospitalized for vertebral fractures in France in 2009. Only 6.4 % of them were operated by vertebroplasty; these patients were younger and healthier than non-operated patients.

Do parents understand the medical information provided in paediatric emergency departments? A prospective multicenter study.

Aim:   We evaluated the extent to which parents understood the medical information about hospitalization of their child in an emergency department and looked for characteristics likely to increase the risk of poor comprehension.

Methods:   Prospective multicenter study in thirteen paediatric emergency departments. The parents and doctors completed questionnaires based on closed-ended questions with a common core of four items: reasons of hospitalization, diagnosis, treatment and seriousness of child condition.

Transplantation in patients with SCID: mismatched related stem cells or unrelated cord blood?

Pediatric patients with SCID constitute medical emergencies. In the absence of an HLA-identical hematopoietic stem cell (HSC) donor, mismatched related-donor transplantation (MMRDT) or unrelated-donor umbilical cord blood transplantation (UCBT) are valuable treatment options. To help transplantation centers choose the best treatment option, we retrospectively compared outcomes after 175 MMRDTs and 74 UCBTs in patients with SCID or Omenn syndrome.

Cell lines expressing mutant FX proteins to generate proteins with reduced rate of fucosylation: WO2010/141478.

Background: The application (WO 2010/141478) is in the field of glycobiology and deals with the synthesis of recombinant proteins with a reduced rate of fucosylation.

Objective: It aims at generating mammalian cell lines that express mutant forms of GDP-4-keto-deoxy-mannose-3,5,-epimerase-4-reductase (FX) and cells that conditionally fucosylate proteins.

Methods: Mutant forms of FX were synthesized, and mammalian cell lines genetically engineered to express mutant FX proteins and the protein of interest.

Parthenogenetically activated human oocytes and parthenogenetic embryonic stem cells: US20100233143.

Background: The application (US20100233143) is in the field of embryonic stems cells (ESCs) and the generation of ESCs from parthenogenetically activated human oocytes.

Objective: It aims at determining optimal conditions for parthenogenetically activating human oocytes.

Methods: Oocytes isolated from female donors were activated in vitro in the presence of an ionophore at high oxygen (O(2)) tension and by a serine-threonine kinase inhibitor under low O(2) tension.

Modulation of GDP-fucose level for generating proteins with reduced rate of fucosylation (WO2010141855).

Background: The application (WO2010141855) is in the field of glycobiology, and involves the control of the rate of fucosylation of proteins by exogenous factors.

Objective: It aims at controlling the rate of protein fucosylation with inhibitors (drugs or nucleic acid antagonists) of enzymes involved in the synthesis of GDP-fucose.

Methods: Mammalian cell lines were cultured in the presence of inhibitors, for example, siRNA.

Chimeric proteins comprising the constant region of immunoglobulins for treating hemophilia B (WO2005001025).

The application (WO2005001025) details recombinant fusion proteins attached to the constant region of heavy chains of immunoglobulins. They are found to be particularly useful for the treatment of hemostatic disorders, such as hemophilia B. It aims at engineering chimeric proteins comprising of a single molecule of human factor IX (FIX) and the constant region (Fc domain) of one or two heavy chain(s) of human IgG (rFIXFc).

Neurogenic drugs and compounds to treat CNS diseases and disorders.

Neurological diseases and related conditions affect an estimated 1 billion of individuals worldwide [1]. There is still no cure for neurological diseases and disorders, barely a few treatments more or less efficient. This mandates the design and development of novel paradigms and strategies, to discover and develop new treatments and cures for these diseases.

Neurogenesis, NSCs, pathogenesis and therapies for Alzheimer's disease.

Neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS) of mammals. Adult NSCs offer tremendous potential for cellular therapy for the treatment of neurological diseases and injuries, particularly of Alzheimer's disease (AD). The contribution of newly generated neuronal cells of the adult brain to the functioning of the nervous system remains to be elucidated.

Decrease of inpatient mortality for hip fracture in France.

Objective: Hip fracture is the most devastating osteoporotic fracture, increasing the risk of mortality. Recent data suggest a decrease in incidence of this fracture. Few data are available on potential changes in mortality.