Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

Disease fatality associated with Ebola, SARS-CoV and dengue infections in humans is attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses. Interleukin (IL)-6 acts as a mediator between pro- and anti-inflammatory reactivity by initiating trans- and classical-signaling, respectively. Hence, IL-6 is assumed to provide a target for a broad range of antiviral agents.

An efficient camera calibration technique offering robustness and accuracy over a wide range of lens distortion.

In the field of machine vision, camera calibration refers to the experimental determination of a set of parameters that describe the image formation process for a given analytical model of the machine vision system. Researchers working with low-cost digital cameras and off-the-shelf lenses generally favor camera calibration techniques that do not rely on specialized optical equipment, modifications to the hardware, or an a priori knowledge of the vision system. Most of the commonly used calibration techniques are based on the observation of a single 3-D target or multiple planar (2-D) targets with a large number of control points.

Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus.

In patients with diarrhea caused by Vibrio parahaemolyticus, antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness.

Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139.

Investigations were carried out to study the production of factors associated with the innate immune response in the systemic and mucosal compartments in adults and children infected with Vibrio cholerae O1 and V. cholerae O139. The levels of nonspecific mediators of the innate defense system, i.