Publications by authors named "Tatyana Shamanskaya"
Article Synopsis
- Primary neuroblastoma is the most common solid tumor outside the brain in children, often found in the abdomen, particularly the adrenal glands.
- * It can also occur in the thoracic region, especially in the posterior mediastinum.
- * This text discusses a rare case of primary neuroblastoma located in the thymus of a pediatric patient.
Introduction: Between 5 and 15% of children with neuroblastoma (NB) present with or develop spinal canal invasion (SCI). The majority of these children have symptoms of epidural compression of spinal cord and/or spinal nerves. Treatment of NB-SCI is considered an emergency but its modalities are not yet well-established.
View Article and Find Full Text PDFBackground: In recent years, many research groups have attempted to identify a subgroup of "ultra-high risk" patients within the high-risk neuroblastoma (NB) category. The aim of our study was to evaluate the prognostic significance of parameters derived from pretherapeutic I-meta-iodobenzylguanidine ([ I]mIBG) integrated single photon emission computed tomography and computed tomography in high-risk patients with NB.
Methods: The established parameters metabolic tumor volume (MTV), maximal standardized uptake value (SUV ) and the novel parameter tumor asphericity as well as clinical (age, stage) and genetic factors (1p/11q deletions and MYCN amplification) were analyzed in this single-center retrospective study of high-risk patients with newly diagnosed NB.
Article Synopsis
- * Results showed that younger children (under 1.5 years) had much better survival rates (91% overall survival) compared to older children (61% overall survival), with high-risk factors like stage 4 and N-myc amplification leading to poorer outcomes.
- * Notably, treatment with anti-GD2 antibodies significantly improved survival rates in high-risk patients, indicating the need for better cancer registration to enhance understanding and treatment of neuroblastoma across Europe.
The tumor-associated ganglioside GD2 represents an attractive target for cancer immunotherapy. GD2-positive tumors are more responsive to such targeted therapy, and new methods are needed for the screening of GD2 molecular tumor phenotypes. In this work, we built a gene expression-based binary classifier predicting the GD2-positive tumor phenotypes.
View Article and Find Full Text PDFMalignant rhabdoid tumor (MRT) of the liver is a rare, highly aggressive tumor of early childhood. We report a 6-month-old boy who was diagnosed with MRT of the liver and presented with spontaneous tumor rupture. The patient underwent intensified chemotherapy and a radical surgical procedure.
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