Publications by authors named "Tatyana S Konstantinova"
Currently, eculizumab is the main effective treatment for paroxysmal nocturnal hemoglobinuria (PNH). The aim of this randomized multicenter noninferiority study was to evaluate the efficacy and safety of the Biosimilar (Elizaria) in comparison with the Originator (Soliris) in patients with PNH. Biosimilar and Originator were administered at a dose of 600 mg weekly for 4 weeks at the initial stage in naive patients, as well as for maintenance therapy at a dose of 900 mg every 2 weeks in all patients.
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- Gravitational unloading during space missions can change muscle fiber types from slow-twitch to fast-twitch and reduce muscle electrical activity.
- Plantar mechanical stimulation (PMS) has been found to help maintain muscle activity and promote nitric oxide (NO) production, which aids in muscle fiber maintenance.
- A study showed that PMS during hindlimb unloading in rats increased NO levels, and blocking NO production diminished the benefits of PMS, indicating that NO is crucial for preventing fiber-type changes and maintaining muscle function.
C-reactive protein, cystatin C, myoglobin, and D-dimer represent the inflammatory or thromboembolic status of the patient and play important roles in early diagnostics of acute myocardial infarction. Each protein can indicate some health problems, but their simultaneous detection can be crucial for differential diagnostics. The express analysis of these proteins in a small drop of plasma was developed using magnetic beads.
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