Serum and local IL-4, IL-5, IL-13 and immunoglobulin E in allergic rhinitis.

Introduction: Allergic rhinosinusitis (AR) is a clinical manifestation of a type 1 hypersensitive reaction. A complex of reactions involving components of the immune system - cells, mediators, cytokines, neuropeptides, adhesion molecules etc., are involved in the manifestation of the disease symptoms.