Publications by authors named "Tatyana I Pospelova"
BMC Med Genomics
March 2019
Article Synopsis
- The study investigates how TP53 dysfunction occurs in diffuse large B-cell lymphoma by examining gene mutations, promoter methylation, and allelic imbalance.
- Researchers analyzed DNA from 74 patients and found that most mutations affected the TP53 gene's DNA-binding domain, with specific codons being mutation hotspots.
- The findings suggest a two-step process in tumor formation, where initial mutations or methylation increase cancer risk, followed by the loss of the normal TP53 allele, which is necessary for tumor development.
