Publications by authors named "Tatyana A Samura"
Article Synopsis
- The study focused on the relationship between microvesicles from dying endothelial cells and different types of chronic heart failure (HF).
- The research involved 388 HF patients, including those with reduced, preserved, and mid-range left ventricular ejection fractions.
- Key findings indicated that while some microvesicle markers were similar in certain HF patients, specific markers, especially CD144/annexin V MVs, were significantly higher in HFrEF patients and could enhance prediction capabilities for heart failure outcomes.
Background: The decreased number and impaired functions of endothelial progenitor cells (EPCs) may associate with cardiovascular disease (CV) including atherosclerosis. However, the role of vistafin in regulation of angiogenic EPC subset maturation in T2DM patients without known atherosclerosis is still not fully understood.
The Aim Of The Study: To investigate an association of serum vistafin level and number of circulating EPCs in T2DM patients beyond known CV disease.
Article Synopsis
- Chronic heart failure (CHF) is a major cause of cardiovascular-related deaths, and current risk models need to be improved; this study investigates if a biomarker risk prediction score can enhance three-year risk assessments for cardiovascular outcomes in CHF patients.
- The study followed 388 CHF patients over an average of 2.76 years, recording 285 cardiovascular events (43 deaths, 242 readmissions) while measuring various biomarkers such as NT-pro-BNP, galectin-3, and hs-CRP.
- The results indicate that specific biomarkers are independent predictors of clinical outcomes and that a calculated cardiovascular risk index could help differentiate patient survival prospects based on their risk scores.
Article Synopsis
- The study aimed to determine if circulating microparticles linked to cell death can help predict cardiovascular risks in patients with congestive heart failure (CHF) over three years.
- During a follow-up of 2.32 years involving 388 patients, 110 cardiovascular events, including 43 deaths, were recorded, highlighting the serious nature of CHF.
- Key factors linked to these outcomes included certain biomarkers (like NT-pro-BNP and hs-CRP) and specific types of apoptotic microparticles, suggesting that analyzing these could enhance risk assessment for patients with CHF.
Background: Subclinical hypothyroidism (SH) is diagnosed biochemically by the presence of normal serum free thyroxine concentration, in conjunction with an elevated serum thyroid-stimulating hormone level. Recent studies have demonstrated the frequent association between SH and cardiovascular diseases and risk factors.
Objectives: To evaluate the impact of SH on patterns of circulating endothelial-derived microparticles, (EMPs) among chronic heart failure (CHF) patients.
Unlabelled: The study aim was to evaluate the impact of dysmetabolic comorbidities including subclinical hypothyroidism (SH) on pattern of circulating endothelial-derived microparticles (EMPs) in chronic heart failure (CHF) patients.
Methods: It was retrospectively involved a cohort of 388 patients with CHF. Fifty three CHF subjects had SH and 335 patients were free from thyroid dysfunction.
Background: Chronic heart failure (CHF) has been remained a leading cause of cardiovascular morbidity and mortaluty. The risk stratification of CHF individuals based on clinical criteria and biomarkers' models may improve medical care and probably increase efficacy of treatment strategy. However, various predictive models approved for CHF patients appear to be distinguished in their prognostications.
View Article and Find Full Text PDFBackground: Decreased circulating endothelial progenitor cells (EPCs) are considered as strong and robust biomarkers for the prediction of cardiovascular outcomes in diabetic populations. The perspectives for modulating EPCs levels in T2DM with known coronary artery disease (CAD) with different drugs, affected mechanisms of improving mobilization of EPCs from tissue, are not still understood.
Aims: To evaluate an effect of angiotensin-2 receptor blocker valsartan on circulating level of EPCs in diabetic patients with asymptomatic CAD.
Introduction: Serum uric acid (SUA) is considered a marker for natural progression of chronic heart failure (CHF) mediated cardiovascular remodelling. CHF associates with declining of circulating mononuclear progenitor cells (MPCs). The objective of this study was to evaluate the interrelationship between SUA concentrations and proangiogenic MPCs in ischemic CHF patients.
View Article and Find Full Text PDFBackground: Acutely decompensated chronic heart failure (ADHF) is considered a life-threatening event. Despite contemporary treatment strategies of ADHF, frequent recurrent hospitalizations due to other cardiovascular reasons after discharge of patients from hospital occur. The objective of the study was to examine the prognostic value of circulating endothelial-derived apoptotic microparticles (EMPs) to mononuclear progenitor cells (MPCs) ratio for post-discharge patients with clinical stabilization after ischemic ADHF.
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