Engineering Perovskite Hydroxide as a Cold-Adapted Oxidase Mimic for Construction of the Robust Low-Temperature Adaptive Biosensors.

Traditional biological detection methods rely on signal amplification strategies such as enzymatic catalysis or nucleic acid amplification. However, their efficiency decreases in low-temperature environments, compromising their detection sensitivity. To break the loss of enzyme catalytic activity at low temperatures, research on cold-adaptive nanozymes has attracted much attention.

Silicon/Silica Colloidal Waste in the Semiconductor Industry: Challenges in Recovery and Potential Use.

The backgrinding of silicon (Si) wafers has resulted in a loss of ∼70% of valuable Si materials. Consequently, an effluent known as diluted backgrinding wastewater (DBGW) is generated, containing nanosized silicon/silica colloids. Here, we discussed the challenges associated with the effective separation of Si-based waste from the DBGW based upon two perspectives, namely, a nanosized effect and a colloidal stability effect.

Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models.

Postoperative abdominal adhesions are the leading cause of bowel obstruction and a cause of chronic pain and infertility. Adhesion formation occurs after 50 to 90% of abdominal operations and has no proven preventative or treatment strategy. Abdominal adhesions derive primarily from the visceral peritoneum and are composed of polyclonally proliferating tissue-resident fibroblasts.

Refugium amidst ruins: Unearthing the lost flora that escaped the end-Permian mass extinction.

Searching for land refugia becomes imperative for human survival during the hypothetical sixth mass extinction. Studying past comparable crises can offer insights, but there is no fossil evidence of diverse megafloral ecosystems surviving the largest Phanerozoic biodiversity crisis. Here, we investigated palynomorphs, plant, and tetrapod fossils from the Permian-Triassic South Taodonggou Section in Xinjiang, China.

Mechanistic Insights into Regioselectivity and Its Evolution in On-Surface Polymerization.

Surface-catalyzed polymerization is crucial in both chemical science and industrial manufacturing, yet achieving regioselective radical polymerization on the surface remains challenging. Here, we demonstrate the regioselective Ullmann polymerization of nonsymmetrical 2,8-dibromoquinoline (DBQ) on an Au(111) surface. By combining scanning tunneling microscopy, density functional theory calculations, and kinetic modeling, we reveal the regioselectivity and its evolution with surface temperature at the molecular level.

The effect of swine insurance participation on swine production efficiency: Evidence from China.

How does swine insurance affect the swine production efficiency in China? We focus on micro-survey data from 582 swine farmers in Liaoning Province, and uses the propensity score matching method (PSM) and mediated effects model for the empirical examination. The results indicate that swine insurance positively impacts production efficiency, compared to uninsured farmers, those who participate in swine insurance exhibit a 4.7% improvement in production efficiency.

Atomistic insights into the humidity response of nanocellulose: a molecular dynamics study.

Context: TEMPO-oxidized cellulose nanofibers (TOCNFs) show significant potential for developing high-performance resistive humidity sensors due to their hydrophilicity and structural adaptability. However, the underlying atomic-scale mechanisms governing their humidity response remain poorly understood. Using molecular dynamics simulations, this study investigates how crystal facets, nanopore widths, and humidity levels influence the surface wettability, water permeability, and swelling of TOCNFs.

Effects of different feeding strategies on egg production, eggshell quality, tibial mass and intestinal calcium transporter expression in laying hens.

1. This study examined feeding practices that could affect the expression of intestinal calcium transporter gene, tibial mass, eggshell quality and production performance in 25-week-old Hy-Line Brown Laying Hens.2.

Soil depth exerts greater effect on bacterial community than spatial structure in Longmenshan fault zone.

Unlabelled: The diversity patterns and drivers of soil microbial communities across spatial distances have been extensively investigated over the recent years. However, whether microbial communities in surface and subsurface soils showed an identical spatial distribution pattern at a small regional scale has not been fully confirmed. For this, we investigated the linkage between soil water content (SWC), pH as well as nutrient contents and soil bacterial diversity and communities in different soil layers in the Longmenshan fault zone in Sichuan Province, China.

Exercise addiction in college students: the impact of body dissatisfaction, stress, physical activity and gender.

Introduction: Engaging in physical activity is commonly regarded as beneficial to health. However, exercise addiction may arise when enthusiasm for exercise reaches a level that disrupts life balance and overall well-being. Factors influencing college students' exercise addiction remain largely unknown.

Transcriptome analyses reveal key genes related to pod dehiscence of adzuki bean ().

Unlabelled: To investigate the mechanism of pod dehiscence in adzuki bean, RNA sequencing was utilized to analyze transcriptomes in the ventral and dorsal sutures of pods from two dehiscence-resistant accessions and two dehiscence-susceptible accessions. A total of 943 differentially expressed genes (DEGs) were identified. Through the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic enrichment pathways, 34 genes related to pod dehiscence were identified.

Long-term consumption of green tea protects the mental health of middle-aged and older adult men by improving inflammation levels.

Background: Middle-aged and older adult men are at a heightened risk of depression. Green tea, as a popular beverage, has drawn widespread attention for its health benefits. However, there remains controversy over the effects of green tea on combating depression and regulating hormones.

A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy.

Iron deficiency anemia (IDA) is a global health concern, particularly affecting women and children of reproductive age. Although oral iron supplements are the standard treatment for IDA, their bioavailability is often compromised by food interactions, and they are associated with significant gastrointestinal side effects. To overcome these limitations, we developed a novel iron nano-supplement, TA-Fe NPs, based on metal-polyphenol networks (MPNs) formed through the coordination of tannic acid (TA) and Fe.

Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway.

Diabetic infected bone defect remains a great challenge in clinical practice, with delayed healing characterized by bacterial infection and cellular disfunction caused by oxidative stress. Hence, a novel self-healing multifunctional Ag@PEG-4OI/EXO hydrogel is introduced for improving healing of diabetic infected bone defect. 4-octyl itaconate, a derivative of the metabolite itaconate, has been proved that which performs antioxidant and mitochondria-protected properties.

Zinc finger protein ZC3H18 is abnormally expressed in esophageal cancer tissues and facilitates the proliferation of esophageal cancer cells.

Introduction: Esophageal cancer presents significant challenges due to the limited efficacy and severe side effects associated with conventional treatments. The identification of epigenetic regulatory molecules that are aberrantly expressed in tumors is crucial for elucidating the mechanisms underlying the development and progression of esophageal cancer.

Methods: We performed high-throughput methylation level analysis on cancerous and adjacent tissues from 25 patients, identifying the differentially methylated gene utilizing Bismark software and data from TCGA.

Causal Relationship Between Intelligence, Noncognitive Education, Cognition and Urinary Tract or Kidney Infection: A Mendelian Randomization Study.

Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, and which risk factors mediate this causal relationship remains unknown.

Methods: The intelligence (n=269,867), noncognitive education (n=510,795) and cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals of European ethnicities. The genetic associations between these factors and urinary tract or kidney infection (UK Biobank, n=397,867) were analyzed using linkage disequilibrium score regression.

Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog25) in Chinese healthy male volunteers.

There are approximately 537 million adults with diabetes worldwide, and insulin still plays an important role in its treatment. However, the long-term use of insulin imposes a significant financial burden on patients. This study aims to explore the pharmacokinetic (PK)/ pharmacodynamic (PD) parameters of generic premixed insulin lispro 25 (25% insulin lispro and 75% protamine zinc lispro) and evaluate the bio-equivalence between generic and brand-name preparations to reduce medical costs while ensuring the effectiveness and safety of treatment.

Pressure-Driven Circularly Polarized Luminescence Enhancement and Chirality Amplification.

Achieving ultrahigh-color-purity circularly polarized luminescence (CPL) in low-dimensional chiral perovskites is challenging due to strong electron-phonon coupling caused by lead halide octahedral distortion. Herein, the circularly polarized piezoluminescence behaviors of six novel chiral perovskites, (/-3-XPEA)PbBr (PEA = phenethylamine; X = F, Cl, Br), were systematically investigated. Upon compression, (/-3-ClPEA)PbBr exhibits significant piezofluorochromic behaviors, transforming from yellow CPL to ultrahigh-color-purity deep-blue CPL.

Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization.

Background: The relationship between Metabolic Syndrome (MetS) and ovarian dysfunction has been widely reported in observational studies, yet it remains not fully understood. This study employs genetic prediction methods and utilizes summary data from genome-wide association studies (GWAS) to investigate this causal link.

Methods: We employed a bidirectional two-sample Mendelian Randomization (MR) analysis utilizing MetS and ovarian dysfunction summary data from GWAS.

Unveiling radiobiological traits and therapeutic responses of BRAF-mutant colorectal cancer via patient-derived organoids.

Background: Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In the quest to enhance the therapeutic efficacy in CRC, the interplay between genetic mutations and RT sensitivity has emerged as a pivotal yet enigmatic area.

Methods: We harness the fidelity of patient-derived organoids (PDOs) to dissect the molecular landscape of radiosensitivity, with a particular emphasis on BRAF mutations.

Can some algorithms of machine learning identify osteoporosis patients after training and testing some clinical information about patients?

Objective: This study was designed to establish a diagnostic model for osteoporosis by collecting clinical information from patients with and without osteoporosis. Various machine learning algorithms were employed for training and testing the model, evaluating its performance, and conducting validations to explore the most suitable machine learning algorithm.

Methods: Clinical information, including demographic data, examination results, medical history, and laboratory test results, was collected from inpatients with and without osteoporosis.

Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy.

Thyroid cancer as one of the most prevalent malignancies of endocrine system, has raised public concern and more research on its mechanism and treatment. And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, plenty of metabolic pathways are reprogrammed to accommodate tumor microenvironment.

Association between FEV/FVC levels and all-cause mortality in the general population.

Background: The ratio of the forced expiratory volume in 1 s (FEV) to the forced vital capacity (FVC) is an essential tool for the diagnosis of chronic obstructive pulmonary disease (COPD). However, the relationship between levels of FEV/FVC and mortality in the general population remains unclear, particularly its non-linear relationship. Therefore, we aimed to explore the association between the FEV/FVC and all-cause mortality in the general population.