Publications by authors named "Tatsuya Tokuda"

Understanding consumer preferences and behavior is a major goal of consumer-oriented companies. The application of neuroscience to this goal is a promising avenue for companies. Previously, we observed a positive correlation during actual cosmetic use between the right dorsolateral prefrontal cortex (dlPFC) activity, measured by functional near-infrared spectroscopy (fNIRS), and the associated willingness-to-pay (WTP) values.

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  • The study investigated the effects of guanfacine extended release (GXR) on inhibitory control in children with ADHD using functional near-infrared spectroscopy (fNIRS).
  • Twelve children aged 6-10 took part in a double-blind crossover trial, performing a go/no-go task before and after either GXR or a placebo.
  • Although the main analysis showed no significant medication effects on the right prefrontal cortex, a secondary analysis revealed significant changes in the right angular gyrus, suggesting it could serve as a biological marker for assessing GXR's impact on cognitive performance in ADHD.
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  • English is considered a global language, but learning it as a second language is still challenging for speakers of languages like Japanese, which are distantly related to English.
  • Previous studies on language translation have shown brain activation in areas like Broca's area and the dorsolateral prefrontal cortex, mainly for languages with closer linguistic connections.
  • Using fNIRS, this study found that brain activation patterns during Japanese to English translation varied significantly based on English proficiency, with advanced learners showing specific activation in Broca's area for low-familiarity words, while elementary learners activated the left temporal area regardless of familiarity.
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It has been reported that children with attention-deficit hyperactivity disorder (ADHD) have impairment in the recognition of angry but not of happy facial expressions, and they show atypical cortical activation patterns in response to facial expressions. However, little is known about neural mechanisms underlying the impaired recognition of facial expressions in school-aged children with ADHD and the effects of acute medication on their processing of facial expressions. We aimed to investigate the possibility that acute administration of methylphenidate (MPH) affects processing of facial expressions in ADHD children.

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  • - The study explores how brain connectivity changes dynamically during rest and in response to tasks, specifically using functional near-infrared spectroscopy (fNIRS) to measure brain signals in children performing a Go/No-Go (GNG) task.
  • - It compares 21 typically developing children with 21 age-matched children with ADHD, focusing on differences in task-related connectivity states that arise during the task.
  • - Four distinct connectivity states were identified, with two being predominant during task performance and showing strong connections within the frontoparietal network, while ADHD children displayed reduced occurrence of these dominant states and increased activation of other connectivity patterns.
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  • Connectivity issues are linked to ADHD, with research focusing on how these issues impact children during both resting states and task performance.
  • In a study, 23 control and 36 ADHD/autism-comorbid children were analyzed using functional near-infrared spectroscopy while performing an attention task, revealing distinct differences in brain connectivity.
  • The study found that while control kids maintained stable connectivity, ADHD kids showed mixed connectivity patterns; notably, connectivity biomarkers were more effective for screening ADHD than brain activation indicators.
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Attention deficit/hyperactivity disorder (ADHD) has been frequently reported as co-occurring with autism spectrum disorder (ASD). However, ASD-comorbid ADHD is difficult to diagnose since clinically significant symptoms are similar in both disorders. Therefore, we propose a classification method of differentially recognizing the ASD-comorbid condition in ADHD children.

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Use of applied neuroscience to complement traditional methods of consumer research is increasing. Previously, fMRI has shown that prefrontal activity contains information relating to willingness-to-pay (WTP). The aim of the present study was to determine if functional near infrared spectroscopy (fNIRS) can record WTP-related brain activation in the dorsolateral prefrontal cortex (DLPFC) during a single, real use of cosmetic products.

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  • Functional near-infrared spectroscopy (fNIRS) is affected by motion artifacts and physiological noises, which reduce its effectiveness in detecting brain activity and increase the chance of statistical errors.
  • To tackle this issue, researchers developed an adaptive algorithm that identifies and selects noise-free blocks from fNIRS data, allowing for better analysis while maintaining sample size.
  • The algorithm uses specific noise criteria and was successfully validated with datasets from children with ADHD, optimizing the analysis for reproducibility across varying conditions and datasets.
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Autism spectrum disorder (ASD) is characterized by impairment in social communication and the presence of restricted and repetitive behaviors and interests. Executive function impairment is reportedly partially responsible for these symptoms. Executive function includes planning, flexibility, and inhibitory control.

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