Synthesis and Characterization of Amphiphilic Diblock Polyphosphoesters Containing Lactic Acid Units for Potential Drug Delivery Applications.

Multistep one-pot polycondensation reactions synthesized amphiphilic diblock polyphosphoesters containing lactic acid units in the polymer backbone. At the first step was synthesized poly[poly(ethylene glycol) H-phosphonate--poly(ethylene glycol)lactate H-phosphonate] was converted through one pot oxidation into poly[alkylpoly(ethylene glycol) phosphate--alkylpoly(ethylene glycol)lactate phosphate]s. They were characterized by H, C {H},P NMR, and size exclusion chromatography (SEC).

Design of a Program to Learn the Nursing Process by Introducing Digital Stories - For the Promotion of Patient Understanding.

Nursing students have a problem to develop real images of patients by using paper patient-based learning as the initial program to learn the process of nursing care. This paper presents a learning program for the promotion of patient understanding, designed by focusing on digital stories and workshops held in classes.

Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals.

Associations of polymorphisms in the angiotensin I-converting enzyme (ACE), apolipoprotein B (APOB) and apolipoprotein E (APOE) genes with hypertension and variations in lipid serum levels were evaluated in 184 Afro-Brazilians with a familial history of coronary artery disease (CAD). ACE (Ins/Del) and APOB (Ins/Del, XbaI, and EcoRI) and APOE (HhaI) polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses on agarose, and polyacrylamide gel electrophoresis. Serum lipids were measured by means of routine enzymatic assays.