Publications by authors named "Tatsuya Miyanaga"
Article Synopsis
- The Gerbode defect is a rare condition that creates an unusual connection between the left ventricle and right atrium, often resulting from severe cases of aortic infective endocarditis, particularly caused by Group B Streptococcus.
- A 60-year-old man with diabetes developed serious complications after a surgery, leading to a diagnosis of infective endocarditis with significant heart valve issues.
- Despite initial difficulties in identifying the defect, advanced imaging techniques revealed the life-threatening connection, prompting urgent surgical intervention including valve replacement and closure of the defect.
Alkaptonuria is an inherited metabolic disease caused by a genetic deficiency of homogentisate 1,2-dioxygenase and characterized by dark-brown connective tissue related to the deposition of oxidized homogentisic acid. Pigment deposition is also observed in the cardiovascular system, such as in the coronary arteries, cardiac valves, and aorta. Because aortic stenosis may develop secondary to pigment deposition-related calcification at the aortic valve, aortic valve replacement may be necessary for severe aortic valve disease.
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