Publications by authors named "Tatsuya Hirokawa"
Predicting elevated natriuretic peptide in chest radiography: emerging utilization gap for artificial intelligence.
Eur Heart J Imaging Methods Pract
January 2024
Article Synopsis
- A study evaluated an AI model's ability to predict elevated brain natriuretic peptide (BNP) levels from chest radiograms, focusing on its impact on healthcare professionals' diagnostic accuracy.
- The AI model was developed using data from over 8,000 chest images and demonstrated high performance metrics, including an accuracy of 85.5% and a receiver-operating-characteristics area-under-curve score of 0.929.
- Results showed that the AI assistance significantly improved diagnostic accuracy for both experienced and early-career healthcare professionals, with early-career professionals outperforming veterans when using the AI tool.
Article Synopsis
- A man in his 30s was found dead after multiple insulin injections in his abdomen.
- Autopsy results revealed tissue damage in the lungs and brain, with high insulin levels at the injection sites but low in the blood and kidneys.
- Determining the cause of death from insulin injections can be complicated, as elevated insulin is usually localized at the injection site rather than in systemic circulation.
Article Synopsis
- - The study aimed to investigate the social and medical background of alcohol dependence and develop strategies to prevent alcohol abuse.
- - Analysis of postmortem data from 1,694 individuals over a span of 10 years revealed that 17.9% tested positive for alcohol, with notable differences in age and underlying medical conditions between the positive and negative groups.
- - Findings indicated higher rates of blunt injuries and mental disorders in the alcohol-positive group, highlighting the need for targeted interventions to address the social issues linked to alcohol-related deaths.
This study was designed to examine the pathophysiological differences in interleukin (IL) and structural protein levels between central nervous system (CNS) disorders associated with heat stroke and CNS stimulants. We measured the concentrations of IL-6, IL-8, neuron-specific enolase (NSE), and myelin basic protein (MBP) in blood and cerebrospinal fluid (CSF) from 87 autopsy cases. In addition, to examine changes in each marker, we cultured nerve cells at 40 °C as a heat stroke model and administered 4-aminopyridine and ephedrine in cultured cells as a CNS stimulant model.
View Article and Find Full Text PDFThis study aimed to investigate the changes associated with acute systemic hypoxia in the endocrine system, particularly in pancreatic tissues. The investigation was based on macroscopic, pathohistological, biochemical, and molecular biological findings in cell lines and human cadavers. The results showed that cases of death due to asphyxia more frequently showed severe subcapsular/interstitial hemorrhage versus the other causes of death.
View Article and Find Full Text PDFA patient with no medical history was admitted to our hospital with consciousness disturbance and diagnosed with intracerebral hemorrhaging in the bilateral hemisphere based on computed tomography. A blood test showed an abnormal coagulation capacity. He died of intracerebral hemorrhaging 11 hours after the onset.
View Article and Find Full Text PDFBackground/aim: The telomerase reverse transcriptase (TERT) promoter has a regulatory single nucleotide polymorphism (rSNP), rs2853669, and occasionally shows point mutations C228T and C250T. Although C228T and C250T have been well examined to increase TERT promoter activity and are known as risk factors for thyroid carcinoma, the significance of rs2853669 has not been well investigated. This study aimed to clarify the influence of rs2853669 on TERT promoter activity in thyroid carcinoma cells.
View Article and Find Full Text PDFFollicular thyroid neoplasm is a common tumor, and consists of follicular thyroid adenoma (FTA) and carcinoma (FTC). The mechanisms of tumor development of FTA and FTC are not well-understood. Single-nucleotide polymorphisms (SNPs) and point mutations in the telomerase reverse transcriptase (TERT) promoter have been associated with tumor development of many cancers.
View Article and Find Full Text PDFPapillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Point mutations in the telomerase reverse transcriptase (TERT) promoter, C228T and C250T and oncogene BRAF have been investigated as risk factors for PTC. However, little research has been done on the single nucleotide polymorphism rs2853669 in the TERT promoter in PTC.
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