Publications by authors named "Tatsuro Sassa"
Article Synopsis
- Mutations in Lamin A/C disrupt the structure of cardiomyocytes and contribute to dilated cardiomyopathy (DCM) by trapping the transcription factor TEAD1 at the nuclear membrane.
- Advanced techniques like single-cell RNA sequencing and ATAC-seq were used to explore the molecular mechanisms behind these mutations, revealing an issue with gene expression regulation.
- Targeting the Hippo pathway shows promise for correcting the gene dysregulation caused by these mutations, suggesting a potential treatment avenue for patients with DCM linked to this specific mutation.
Article Synopsis
- This study investigates how the heart changes after a heart attack (myocardial infarction) by analyzing gene expression in mice.
- Researchers discovered that genes related to mechanical stress are active in a specific area (the border zone) around the damaged tissue and are key to how the heart remodels post-MI.
- They found that a gene called Csrp3 is particularly important, as manipulating its levels can help prevent harmful cardiac remodeling, suggesting it plays a protective role in heart recovery.
Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart failure, but it remains elusive whether there is a common pathway to induce both events. Through single-cell RNA-seq, spatial transcriptomics, and genetic perturbation, we elucidate that high-temperature requirement A serine peptidase 3 (Htra3) is a critical regulator of cardiac fibrosis and heart failure by maintaining the identity of quiescent cardiac fibroblasts through degrading transforming growth factor-β (TGF-β). Pressure overload downregulates expression of Htra3 in cardiac fibroblasts and activated TGF-β signaling, which induces not only cardiac fibrosis but also heart failure through DNA damage accumulation and secretory phenotype induction in failing cardiomyocytes.
View Article and Find Full Text PDFMost mediastinal abscesses result from infections after thoracotomy, esophageal perforation or pene- trating chest trauma. This disease is rarely caused by closed blunt chest trauma. All previously reported such cases after closed blunt chest trauma presented with hematoma and sternal osteomyelitis resulting from sternal fracture.
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