Publications by authors named "Tatsuro Matta"
A set of genes in the posterior end of developing mouse embryos shows oscillatory expression, thereby regulating periodic somite segmentation. Although the mechanism for generating oscillation has extensively been clarified, what regulates the oscillation period is still unclear. We attempted to elongate the oscillation period by increasing the time to transcribe Hes7 in this research.
View Article and Find Full Text PDFArticle Synopsis
- During vertebrate development, the primary body axis stretches out and forms somites, which eventually develop into vertebrae, muscles, and skin.
- In zebrafish, the rate of somite formation differs along the body axis, with anterior somites forming faster than those at the posterior.
- This difference is caused by variable timing influenced by retinoic acid, which regulates a gene that controls somite formation; disruptions can lead to malformations in the vertebrate body plan.
Somite segmentation, a prominent periodic event in the development of vertebrates, is instructed by cyclic expression of several genes, including Hes7 and Lunatic fringe (Lfng). Transcriptional regulation accounts for the cyclic expression. In addition, because the expression patterns vary in a cycle, rapid turnover of mRNAs should be involved in the cyclic expression, although its contribution remains unclear.
View Article and Find Full Text PDF