Publications by authors named "Tatsuo Onuki"
Total spontaneous resolution by deracemization of isoindolinones.
Angew Chem Int Ed Engl
December 2012
Article Synopsis
- The study focuses on the separation of 3-hydroxy-3-phenylisoindolin-1-ones using a method called dynamic preferential crystallization.
- These compounds can be racemized by undergoing ring-opening and ring-closing reactions with achiral intermediates in basic conditions.
- By crystallizing from a toluene solution with DBU and using stirring and solvent evaporation, the researchers successfully produced optically active crystals with high enantiomeric excess (ee) values.