Game-Based Promotion of Assertiveness to Mitigate the Effects of Bullying in High School Students: Development and Evaluation Study.

Background: For years, Mexico has reported the highest global incidence of school bullying, with approximately 19% of students going through some form of hostile peer interactions. Despite numerous interventions, these harmful conducts remain deeply entrenched in educational environments.

Objective: To address this issue, we developed Bernstein, a serious game that promotes assertiveness-an essential protective factor that reduces the negative effects of bullying.

Development and Evaluation of a Treadmill-based Video-see-through and Optical-see-through Mixed Reality Systems for Obstacle Negotiation Training.

Mixed reality (MR) technologies have a high potential to enhance obstacle negotiation training beyond the capabilities of existing physical systems. Despite such potential, the feasibility of using MR for obstacle negotiation on typical training treadmill systems and its effects on obstacle negotiation performance remains largely unknown. This research bridges this gap by developing an MR obstacle negotiation training system deployed on a treadmill, and implementing two MR systems with a video see-through (VST) and an optical see-through (OST) Head Mounted Displays (HMDs).

Piton: Investigating the Controllability of a Wearable Telexistence Robot.

The COVID-19 pandemic impacted collaborative activities, travel, and physical contact, increasing the demand for real-time interactions with remote environments. However, the existing remote communication solutions provide limited interactions and do not convey a high sense of presence within a remote environment. Therefore, we propose a snake-shaped wearable telexistence robot, called Piton, that can be remotely used for a variety of collaborative applications.

Synthesis and preclinical evaluation of [C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain.

Purpose: Phosphodiesterase (PDE) 7 is a potential therapeutic target for neurological and inflammatory diseases, although in vivo visualization of PDE7 has not been successful. In this study, we aimed to develop [C]MTP38 as a novel positron emission tomography (PET) ligand for PDE7.

Methods: [C]MTP38 was radiosynthesized by C-cyanation of a bromo precursor with [C]HCN.

Pyrazolo[4,3-]pyrimidine Derivatives as a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor for the Treatment of Anemia.

Inhibition of hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) promotes erythropoietin (EPO) production by stabilizing the HIFα subunit. Thieno[2,3-]pyrimidine identified based on X-ray crystal structure analysis was optimized to lead to the discovery of pyrazolo[4,3-]pyrimidine as the lead compound of orally bioavailable HIF-PHD inhibitors. Conversion of the benzyl moiety in gave pyrazolopyrimidine with high solubility and bioavailability, which increased hemoglobin levels in anemic model rats after repeated oral administration.

Venous architecture of the glabellar to the forehead region.

The precise venous anatomy of the glabellar to the forehead region remains unknown. This study aimed to detail the venous architecture of the glabellar region to the forehead in conjunction with that of the supratrochlear artery to reduce the risk of venous congestion of flaps in this area. Fifteen fresh human cadavers were examined here.

New technique for releasing tension to prevent widening of an abdominal scar.

We developed an easy way to release tension from an abdominal cutaneous suture by plicating the anterior rectus sheath for several centimetres. We used this in two patients and the scars were satisfactory. Plication of the fascia is an easy and effective way of releasing the tension of a cutaneous sutured line.

Anthropometric evaluation of bilateral cleft lip nose with cone beam computed tomography in early childhood: Estimation of nasal tip collapse.

Background: Nasal tip features of cleft lip nose cannot be defined well using conventional measurement methods. Therefore, we developed a new method in which vertical nasal tip (the pronasale) position is evaluated based on the Frankfurt-Horizontal plane. This measurement was applied to bilateral cleft lip patients in early childhood.

Palatoplasty for bilateral oblique cleft of the soft palate accompanied by Tessier number 5·7 cleft.

Craniofacial cleft is a rare congenital deformity in which there are fissures of a facial structure classified by Tessier. A palatoplasty to reconstruct the muscle sling and to close the cleft of the velum was performed. Acceptable postoperative appearance of the velum was seen after 6 months.

A rare case of proboscis lateralis with median cleft lip.

A very rare case of proboscis lateralis is reported. This case is different from previously reported cases due to proboscis lateralis, single nostril, loss of columella, and median cleft lip without holoprosencephaly. In addition, this is considered the first surviving individual with proboscis lateralis accompanied by median cleft lip.

Management of craniofacial hyperostosis in Proteus syndrome.

Proteus syndrome is a rare congenital hamartomatous condition that is characterized by a wide range of malformations, occasionally involving the head and the face. Skin and skeletal developmental malformations are common and may be manifested in significant physical anomalies. In this report, we describe the cases of 2 patients affected by this condition.

Distribution of adipose-derived stem cells in adipose tissues from human cadavers.

Background: Adipose-derived stem cells (ASCs) possess multipotency in vivo and in vitro, and thus are thought to be very promising precursors for use in regenerative medicine. ASCs can be concentrated from adipose tissue by enzymatic digestion and transplanted to increase angiogenesis or for cosmesis. ASC transplants are now being performed in a clinical setting.

Biomechanical analysis of stresses occurring in vertical and transverse scars on the lower leg.

Background: The processes involved in wound healing differ depending on wound tension. However, biomechanically, little is known about how mechanical stimulation actually works on wounds.

Methods: Six isotropic lower leg models were generated from computed tomographic findings with computer-aided design.

How to revise and utilise the cephalogram for craniofacial dysostosis--modification of the porion and the McNamara line.

McNamara line analysis is often utilised in orthognathic surgery and is particularly useful in that it can easily express the extent of maxillo-mandibular deformity quantitatively. However, in craniofacial dysostosis (CFD), the location of the porion (PR) is sometimes displaced inferiorly. The McNamara line depends on the Frankfurt horizontal plane (FH plane), and hence, its deviation is often extremely distorted in CFD.

What happens between pure hydraulic and buckling mechanisms of blowout fractures?

Objective: The present study aims to evaluate how the ratio of the hydraulic and buckling mechanisms affects blowout fracture patterns, when these two mechanisms work simultaneously.

Materials And Methods: Three-dimensional computer-aided-design (CAD)models were generated simulating ten skulls. To simulate impact, 1.

Combined fixation with plates and transmalar Kirschner wires for zygomatic fractures.

After repair of a fractured zygoma, the fixed zygoma occasionally becomes displaced. This phenomenon--generally called "relapse"--is a complication that can be prevented by fixing plural sites with plates. However, this impairs blood supply to the bone, which causes atrophy.

Histological responses of cutaneous vascular lesions following photodynamic therapy with talaporfin sodium: a chicken comb model.

Background: Mono-L-aspartyl chlorin e6 (Talaporfin sodium) is a novel photosensitizer, and is currently being used in photodynamic therapy for various malignant tumors in combination with irradiation with a 664 nm laser. An interesting characteristic of Talaporfin sodium is that the skin photosensitivity after injection of this agent disappears faster than any other existing photosensitizers. This study examined the vascular events that occurred postirradiation in the chicken comb as a capillary malformation model after photosensitization with Talaporfin sodium.

Anal and perianal reconstruction after extramammary Paget's disease using a posterior thigh flap with a thin square wing.

Extramammary Paget's disease regularly requires a wide resection of skin, often including the anal tract. When reconstructing the anal tract, simulating natural anatomy by creating the thinnest possible flap is essential to prevent incontinence. We reconstructed the anal and perianal area using a posterior thigh trilobed flap.

A novel approach to thoracic wall reconstruction based on a muscle perforator.

When reconstructing the thoracic wall, non-adaptation of the suture line is a critical concern, especially when artificial implants are used. Therefore, a reliable and safe flap is required. Based on an anatomical study of cadavers, we decided to dissect the pectoralis major musculo-cutaneous flap into two parts, on the surface and beneath the muscle fascia, while preserving the muscle perforators.

Reconstruction of vulva using pudendal thigh gluteal fold bilobed flap.

In reconstructing a large defect of the vulva, we combined the gluteal fold and the pudendal thigh flaps and made a bilobed flap. Using this gluteal fold pudendal thigh bilobed flap, we reconstructed a vagina with sufficient depth and width. The surrounding skin defect was simultaneously reconstructed.

MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing.

Matrix metalloproteinases (MMPs) have been implicated in wound healing. To analyze the roles of MMP-9 and MMP-13 in wound healing, we generated full-thickness cutaneous wounds in MMP-9 knockout (KO), MMP-13 KO, MMP-9/13 double KO, and wild-type mice. Macroscopic wound closure was delayed in all of the KO mice, as compared with wild-type mice.

Refined simple line closure for macrostomia repair: designing a mucosal triangular flap on the commissure region.

Congenital macrostomia is a relatively rare deformity. A number of different methods for its correction have been reported in the past. Here, we report our refined method of correcting macrostomia.