Evaluating the impact of regulatory action on denosumab-induced hypocalcaemia in Japan.

What Is Known And Objective: Since its introduction in April 2012, denosumab has been administered to approximately 7,300 patients as of August 2012, and 32 cases of serious hypocalcaemia after denosumab administration, including two deaths, have been reported in Japan. A Dear Healthcare Professional Letter of Rapid Safety Communication ('Blue letter') was released to warn about the risks of hypocalcaemia associated with denosumab. The goal of this study therefore was to measure the impact of regulatory action on denosumab-induced hypocalcaemia in Japan by using an electronic medical information database (MID).

Analyzing intent-to-treat and per-protocol effects on safety outcomes using a medical information database: an application to the risk assessment of antibiotic-induced liver injury.

Objective: To apply a causal analysis approach to estimate the intent-to-treat and per-protocol effects in a safety outcome study of the 30-day risk of liver injury associated with antibiotic use (macrolides, penicillin-based antibiotics, and fluoroquinolones).

Research Design And Methods: For each antibiotic class, we constructed a pooled cohort of treated episodes matched with untreated episodes using an electronic medical record database from a university hospital. High-dimensional propensity scores were calculated using baseline patient characteristics, concomitant medications and medical history as surrogate confounders.

Health checkup and telemedical intervention program for preventive medicine in developing countries: verification study.

Background: The prevalence of non-communicable diseases is increasing throughout the world, including developing countries.

Objective: The intent was to conduct a study of a preventive medical service in a developing country, combining eHealth checkups and teleconsultation as well as assess stratification rules and the short-term effects of intervention.

Methods: We developed an eHealth system that comprises a set of sensor devices in an attaché case, a data transmission system linked to a mobile network, and a data management application.

Evaluation of "Portable Health Clinic" with BAN standard for 10K subjects in Bangladesh.

Management system of chronic diseases in developing countries and post-disaster situation has been required. Body area network (BAN, IEEE 802.15.

Storing health data in JPEG: looking at exif area capacity limits.

Formats for data storage in personal computers vary according to manufacturer and models for personal health-monitoring devices such as blood-pressure and body-composition meters. In contrast, the data format of images from digital cameras is unified into a JPEG format with an Exif area and is already familiar to many users. We have devised a method that can contain health data as a JPEG file.

Coffee consumption, serum γ-glutamyltransferase, and glucose tolerance status in middle-aged Japanese men.

Background: Recently, coffee consumption has been related to decreased risk of type 2 diabetes mellitus (DM) among those with high levels of serum γ-glutamyltransferase (GGT). We examined the association between coffee and glucose tolerance, determined by a 75 g oral glucose tolerance test, and the effect modification of serum GGT on the association.

Methods: The study subjects were 5320 men aged 46-60 years who received a health examination at two Self-Defense Forces hospitals from January 1997 to March 2004.