Publications by authors named "Tatsunori Toraishi"
In the present study, a novel wound dressing made of xyloglucan (Xyl)-sucrose (Suc) hydrogel was developed for the treatment of deep wounds including pressure ulcers. The dressing was prepared by casing an aqueous solution of Xyl and sugar and then warming, and a hydrogel sheet was obtained. The in vitro characteristics of these sheets, such as their strength, extensibility, water content, adhesion potential, and water absorption, were examined.
View Article and Find Full Text PDFArticle Synopsis
- The steroid receptor complex includes FKBP51 and FKBP52, which interact with calcineurin inhibitors (CNIs) like tacrolimus (TAC) and cyclosporine (CYA), affecting how steroid-SR complexes move within cells.
- *Research assessed how CNIs impact methylprednisolone (MPSL) sensitivity by comparing different groups of healthy subjects to renal transplant recipients.
- *Findings indicated that the presence of CNIs like TAC and CYA enhances MPSL and cortisol sensitivity, with TAC showing a stronger effect.
Though steroid withdrawal is done in many renal transplant recipients, some patients must restart steroids. Little report has investigated steroid withdrawal under pharmacodynamic monitoring. We assessed lymphocyte sensitivity to endogenous cortisol as a biomarker for determining the safety of steroid withdrawal in renal transplant patients, as we hypothesized that patients hyposensitive to cortisol could not be sufficiently immunosuppressed by their intrinsic cortisol as a substitute for the reduced or withdrawn steroid.
View Article and Find Full Text PDFEvidence of different pharmacokinetics including relationship among AUC, peak, and trough levels between cyclosporine and tacrolimus in renal transplant recipients using new pharmacokinetic parameter--why cyclosporine is monitored by C(2) level and tacrolimus by trough level--.
Biol Pharm Bull
January 2008
Article Synopsis
- - The effectiveness of calcineurin inhibitors in kidney transplant patients is closely linked to how their drug levels are monitored, specifically looking at the area under the concentration-time curve (AUC).
- - For cyclosporine (CYA), blood levels are typically checked 2 hours after taking the drug, while for tacrolimus (TAC), levels are measured just before the next dose (trough concentration).
- - This study compared the blood concentration patterns of CYA and TAC in kidney transplant patients with similar backgrounds, revealing notable differences in their pharmacokinetics and how their levels relate to AUC.