Publications by authors named "Tatsuki Tsuruga"
Background: Coagulopathy is a major cause of morbidity and mortality in COVID-19 patients. Hypercoagulability in COVID-19 results in deep vein thrombosis, thromboembolic complications, and diffuse intravascular coagulation. Microbiome dysbiosis influences the clinical course of COVID-19.
View Article and Find Full Text PDFBronchoscopy with radial-probe endobronchial ultrasound, a guide sheath, and electromagnetic navigation can improve the diagnostic yield of peripheral lung nodules. However, the suitability of specimens for genetic analysis remains unsatisfactory. We hypothesized that a transbronchial biopsy performed after closely approaching the bronchoscope tip to the lesion might provide more suitable specimens for genetic analysis.
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- Idiopathic pulmonary fibrosis is a serious and progressive disease, and the role of matrix metalloproteinase-2 (MMP-2) in this condition is not well understood.
- A study using transgenic mice that overexpress MMP-2 showed reduced inflammation and fibrosis compared to regular mice after lung injury caused by bleomycin.
- The findings suggest that MMP-2 helps protect against pulmonary fibrosis by decreasing cell death (apoptosis) in the lung's epithelial cells.
Apoptosis is a programmed cell death involved in embryogenesis and tissue homeostasis under physiological conditions. However, abnormalities in the process of apoptosis are implicated in the pathogenesis of various diseases. The human microbiota may release products that induce apoptosis of host cells.
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