Publications by authors named "Tatsuki Karino"
This study developed a system to reduce the treatment planning time for cervical cancer brachytherapy. An in-house Excel spreadsheet was developed to streamline dosimetric evaluation by combining external beam radiotherapy and brachytherapy doses, while also displaying daily dose constraints, a novel feature of the system. This system was validated in 46 consecutive patients who underwent intracavitary and interstitial brachytherapy using several applicators and required more complex dose calculation procedures than intracavitary brachytherapy alone.
View Article and Find Full Text PDFHangeshashinto is a traditional Japanese herbal medicine that is widely recognized for its efficacy in relieving mucositis induced by chemotherapy and radiotherapy. We herein present the cases of two patients with head and neck cancer who were clinically diagnosed with severe drug-induced interstitial lung disease (DILD) following Hangeshashinto administration for radiation-induced mucositis. Although Hangeshashinto has beneficial properties, it is also associated with a relatively low incidence of DILD, including some reports of death.
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- * The model was created using CT scans and 3D modeling software, filled with a gelatin gel to mimic human anatomy, and was tested in a hands-on training session with 10 radiation oncologists.
- * Results showed that 90% of participants wanted to incorporate the caudal block technique into their practice, and all expressed interest in using the 3D-printed model for future training.
Purpose: Analyzing dose distributions to regional lymph-node metastases (RLNMs) in locally advanced cervical cancer (LACC) patients undergoing intracavitary and interstitial hybrid brachytherapy (IC/IS).
Methods: Dose distributions of eleven LACC patients with 38 RLNMs, and who received 38 IC/IS sessions were analyzed in EQD, considering RLNM positions and ipsilateral interstitial needles; these RLNMs, excepting the para-aortic region, were classified into four groups.
Results: RLNMs had a median of two ipsilateral interstitial needles per session.
Article Synopsis
- The study aimed to assess how effective and safe it is to use F-fluorodeoxyglucose PET-CT for determining target volumes in intensity-modulated radiation therapy (IMRT) for patients with locally advanced head and neck squamous cell carcinoma (HNSCC).
- A total of 10 patients were treated using IMRT, and the target volumes were evaluated by two radiation oncologists through different imaging modalities, revealing that PET-CT provided less variability in target volume assessments compared to CT or MRI.
- The findings indicated that using PET-CT may allow for a safer reduction in gross tumor volume while achieving good local control, as evidenced by no local recurrence after a median follow-up of 37 months and manageable acute adverse effects.
Article Synopsis
- The study evaluated the effectiveness of hands-on training (HoT) and surveys on 3D image-guided brachytherapy (3D-IGBT) and hybrid brachytherapy (HBT) for cervical cancer among 29 healthcare professionals in Japan.
- Participants completed questionnaires before and after the training, revealing key concerns like applicator insertion, human resource shortages, and pain management; feedback led to adjustments in the HoT content.
- Post-training, a significant reduction in anxiety was noted across all professions, with an average satisfaction score of 9.52 out of 10, indicating that the tailored HoT was successful in addressing participants' concerns.
Article Synopsis
- - The study aimed to explore whether using a hyaluronic acid gel spacer could allow for higher doses and fewer treatment sessions in cervical brachytherapy for uterine cervical cancer patients.
- - In the analysis of 20 patients, those who received the gel spacer (HGI group) showed better dose delivery to the target area (CTV D) while maintaining safety limits for surrounding organs compared to those who didn't receive the gel (non-HGI group).
- - Results indicated that the HGI group experienced significantly lower doses in the rectum during three treatment sessions, suggesting that the gel spacer can enhance treatment efficiency and safety.
MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience.
Clin Transl Radiat Oncol
September 2023
Article Synopsis
- Researchers tested MucoUp®, a hyaluronic acid, as a spacer during brachytherapy for cervical cancer patients.
- In five patients, using MucoUp® improved radiation delivery, raising the dose to the high-risk tumor area to over 80 Gy.
- There were no adverse events reported related to the MucoUp® insertion.
Background/aim: Radiotherapy (RT) has been rarely reported as a cause of tumor lysis syndrome (TLS). Therefore, the patient characteristics and details of RT-induced TLS remain unclear, which may delay diagnosis. Herein, we report a case of palliative RT-induced severe TLS in a patient with multiple myeloma (MM) with skin involvement along with literature review.
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