Publications by authors named "Tatsuki Domon"
Article Synopsis
- Deleting gene expression in specific tissues helps researchers understand the functions of certain proteins, and the Cre-loxP system is a popular method for this purpose in various organisms, including medaka fish.
- The epithelium, being the outer protective layer, is crucial for studying responses to external stimuli, yet there wasn't a specific Cre-driver line available for it in medaka.
- This study successfully developed epithelium-specific Cre-driver lines using CRISPR/Cas9 technology, targeting periplakin and keratin genes, allowing for efficient gene recombination in epithelial tissues for further research.