Twenty nine patients with chronic renal failure associated with severe essential hypertension, 10 of whom being on programmed hemodialysis, were treated with captopril, a converting enzyme inhibitor (n = 21) and sectral-400, a cardioselective beta-blocker (n = 11). Blood pressure (BP) changes and renin-angiotensin-aldosterone system parameters were studied by radioimmunoassay. When given in a daily dose of 25 to 100 mg for a long time, captopril provided a good and satisfactory antihypertensive effect in 9 patients; a weak or no effect was achieved in 9 and 5 patients, respectively.
View Article and Find Full Text PDFThe authors studied the efficacy of plasmapheresis in preoperative management of patients with thyrotoxicosis in intolerance of and resistance to thyrostatic agents. Seventy-three patients were examined. Preoperative management was accomplished by gravitation plasmapheresis (PP) with a PP-0.
View Article and Find Full Text PDFAn original method of quantitation of body inorganic iodine, based upon a simultaneous administration of a known dose of stable and radioactive iodine with subsequent radiometry of the thyroid, was proposed. The calculation is based upon the principle of the dilution of radioactive iodine in human inorganic iodine space. The method permits quantitation of the amount of inorganic iodine with regard to individual features of inorganic space.
View Article and Find Full Text PDFMed Radiol (Mosk)
September 1991
Differences in the rated and actual results were revealed during postoperative plasmapheresis in patients with thyrotoxicosis who did not tolerate or were resistant to thyrostatics. It was assumed that it was caused by a rise of the level of thyroid hormones resulting from heparin premedication. Gravitation plasmapheresis following heparin administration (150-200 U per 1 kg of body mass) was used in a study group of 25 patients.
View Article and Find Full Text PDFThe activity of the renin-angiotensin-aldosterone system (RAAS), excretion of renal prostaglandins, renal hemodynamics, water-electrolyte balance were studied in 110 patients with chronic nephritis with arterial hypertension: 47 with hypertonic nephritis and 63 patients at the stage of renal insufficiency. Some investigations, the results of data processing, an analysis of the results of cross-group comparative studies, and the use of captopril (a drug that inhibits the activity of angiotensin-converting enzymes) confirmed the RAAS involvement in the pathogenesis of arterial hypertension in nephritides. Pathophysiological features of arterial hypertension in nephritides are the following: disturbances of physiological interrelationships between renin plasma activity and the state of water-electrolyte balance; hyperaldosteronism and depression of renal prostaglandin synthesis revealed both in unchanged and lowered renal function.
View Article and Find Full Text PDFA simple and reliable method for the assessment of thyroid function was proposed. Data on a high specificity of the radioactive iodine absorption intensity coefficient to differentiate euthyroid and hyperthyroid patients were obtained. The appropriateness of its use in restricted indications for radioimmunoassays was substantiated.
View Article and Find Full Text PDFRadionuclide roentgenography with 131I-hippuran was performed in 53 patients with various clinical variants and stages of amyloidosis. It showed disorders of renal function even at the initial stages of disease. X-ray findings depended on a stage of amyloid nephropathy and concomitant hypertensive syndrome.
View Article and Find Full Text PDFActive renin (AR) and trypsin-activated inactive renin (IR) were examined in 32 patients with chronic renal failure (CRF). (of these, 25 patients were kept on the programmed hemodialysis) and in 11 normal subjects. As compared with normal subjects, CRF patients manifested a decrease in both AR and IR.
View Article and Find Full Text PDFThe results of a comprehensive radionuclide, ultrasound and thermographic study of 18 patients with toxic thyroid adenoma are presented. It has been shown that during thermographic examination temperature difference over the node and the symmetrical region is insignificant and does not exceed 1 degree C in most of the patients. It equally pertains to the comparison of temperatures over the node and the hottest and coldest points in the cervical region.
View Article and Find Full Text PDFMed Radiol (Mosk)
December 1981
The indices of somatotropin were determined in myocardial infarction patients by means of immunological techniques, and those of blood sugar by the Hagedorn--Jensen technique. Single growth hormone determinations were conducted in 40 myocardial infarction patients, aged 45 to 80 years, with different periods from the onset of the disease. In 23 patients the somatotropin and blood sugar indices were studied dynamically on the 1st--3rd and 7th--10th days of the infarction.
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