Publications by authors named "Tatsiana Varaksa"
Article Synopsis
- Ferredoxins are small proteins that help with important processes in living things, but a specific type called 3Fe-4S ferredoxins hasn't been studied much because they need special conditions to exist.
- Scientists figured out the structure of two types of these ferredoxins, showing how they work with another protein called CYP143.
- The study found that when FdxE connects to CYP143, it changes its shape a bit, which helps in making different kinds of important chemicals.
Structural insights into the effects of glycerol on ligand binding to cytochrome P450.
Acta Crystallogr D Struct Biol
January 2023
New antitubercular drugs are vital due to the spread of resistant strains. Carbethoxyhexyl imidazole (CHImi) inhibits cytochrome P450 CYP124, which is a steroid-metabolizing enzyme that is important for the survival of Mycobacterium tuberculosis in macrophages. The available crystal structure of the CYP124-CHImi complex reveals two glycerol molecules in the active site.
View Article and Find Full Text PDFMycobacterium tuberculosis (Mtb) infection is among top ten causes of death worldwide, and the number of drug-resistant strains is increasing. The direct interception of human immune signaling molecules by Mtb remains elusive, limiting drug discovery. Oxysterols and secosteroids regulate both innate and adaptive immune responses.
View Article and Find Full Text PDFSpreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III clinical trials. Fast SQ109 degradation is attributed to the human liver Cytochrome P450s (CYPs).
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