Publications by authors named "Tatos N Akopian"
In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes, encode two ClpP homologs, ClpP1 and ClpP2, in a single operon. Here we demonstrate that the two proteins form a mixed complex (ClpP1P2) in mycobacteria.
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- BACE1 is an enzyme linked to Alzheimer's disease, and researchers are developing inhibitors by modifying peptides that interact with it.
- New methods were created to quickly analyze and improve these inhibitors, focusing on minimizing the peptide sequences needed for effective binding.
- The study successfully identified new "bis-statine" inhibitors with unique binding characteristics, showcasing peptide spot synthesis as a powerful approach for drug discovery.