Publications by authors named "Tatjana Smiljakovic"
Article Synopsis
- Translational regulation of gene expression is crucial during developmental stages, particularly when transcription is limited, as seen in the maturation of bovine oocytes and early embryos.
- The study highlights the roles of various proteins (like eIF4F components and PABPs) and kinases involved in the phosphorylation of these proteins during the transition from M II stage oocytes to early embryos, showing significant alterations in their abundance and activity.
- Overall, a decrease in poly-(A) binding proteins (PABP1 and 3) is linked to a repression of translation during the early stages of embryonic development, even as some eIF4F complexes are still forming.
In somatic cells, the serine/threonine kinase Akt (or protein kinase B) was shown to contribute to processes linked to cellular growth, cell survival and cell cycle regulation. In contrast to these findings, the function of Akt during the meiosis of mammalian oocytes remains to be investigated. We analysed the phosphorylation pattern and the activity of Akt during meiotic maturation (transition from prophase I to metaphase II) of bovine oocytes.
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