Depression in myasthenia gravis: a heterogeneous and intriguing entity.

Background: Depressive symptoms in myasthenia gravis (MG) are common, may mimic other disease features, and contribute to misdiagnosis and diagnostic delay. Nevertheless, the clinical determinants of depressive symptoms in MG remain poorly studied, in particular their overlap with fatigue. Moreover, studies in MG have rarely looked at distinct depression phenotypes.

Subclinical hyperthyroidism of variable etiology and its influence on bone in postmenopausal women.

Objective: To evaluate the effects of subclinical hyperthyroidism of variable etiology on bone mineral density (BMD) and bone metabolism in postmenopausal women.

Design: T he study included data of 88 postmenopausal women classified into four groups depending on the etiology of subclinical hyperthyroidism: (1) 20 with toxic multinodular goiter without history of clinical hyperthyroidism; (2) 25 on levothyroxine suppressive therapy after thyroidectomy due to differentiated thyroid cancer; (3) 21 with Graves' disease (GD) receiving antithyroid drugs; (4) 22 healthy women matched for age and duration of menopause. In all subjects biochemical markers of bone turnover and B MD were determined.