Publications by authors named "Tatjana Bosnjak-Olsen"
Transforming growth factor-beta 1 (TGF-β1) is a critical regulator of skeletal homeostasis and has diverse effects on osteoblastogenesis. To date, the mechanisms behind the intriguing inhibitory effect of TGF-β1 on osteoblast maturation are not fully understood. Here, we demonstrate a novel mechanism by which TGF-β1 modulates osteoblast maturation through the lysosomal protease legumain.
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- * The NEOLETRIB trial specifically assesses the effectiveness of combining letrozole (an aromatase inhibitor) and ribociclib (a CDK4/6-inhibitor) in ER-positive, HER2-negative luminal A/B breast cancer patients.
- * The study includes comprehensive molecular biology techniques, such as single-cell RNA sequencing, to analyze tumor responses and make better treatment decisions, with the aim of enhancing patient selection for this combination therapy.
Legumain is a lysosomal cysteine protease that has been implicated in an increasing amount of physiological and pathophysiological processes. However, the upstream mechanisms regulating the expression and function of legumain are not well understood. Here, we provide in vitro and in vivo data showing that vitamin D (VD) enhances legumain expression and function.
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