Publications by authors named "Tatjana Bosnjak"
Article Synopsis
- Legumain, a cysteine protease, is involved in normal bodily functions and is linked to diseases like atherosclerosis, osteoporosis, cancer, and neurodegenerative disorders.
- Its primary activity occurs in lysosomes, where it helps process proteins and convert cysteine cathepsins from single to double chain forms.
- Recent research has highlighted legumain's novel functions outside of lysosomes, expanding our understanding of its role in various diseases.
Lansoprazole inhibits the cysteine protease legumain by binding to the active site.
Basic Clin Pharmacol Toxicol
August 2019
Proton pump inhibitors (PPIs) are prodrugs used in the treatment of peptic ulcer diseases. Once activated by acidic pH, the PPIs subsequently inhibit the secretion of gastric acid by covalently forming disulphide bonds with the SH groups of the parietal proton pump, that is the H /K -ATPase. Long-term use of PPIs has been associated with numerous adverse effects, including bone fractures.
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