CCRL2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated .

Unlabelled: Patients with myeloid neoplasms with loss-of-function mutations and erythroid differentiation have poor outcomes, and a better understanding of disease biology is required. Upregulation of interferon-γ (IFN-γ) signaling has been associated with acute myeloid leukemia (AML) progression and chemotherapy resistance, but its drivers remain unclear. In this study, we found that the surface receptor C-C motif chemokine receptor-like 2 (CCRL2) is overexpressed in AML with erythroid differentiation and mutations compared to other AML subtypes and healthy hematopoietic cells.