Evaluation of pigment epithelium-derived factor concentration in equine amniotic membrane homogenate and its vascular endothelial growth factor inhibition effect in tears of dogs with vascularized ulcerative keratitis.

Background: Corneal neovascularization can result from many pathological processes affecting the ocular surface leading to disturbances and opacifications that reduce corneal clarity and may impact vision. In veterinary medicine, the use of topical corticosteroid is contraindicated in the presence of ulcerative keratitis, and there is sparse research regarding safe medical alternatives to inhibit corneal neovascularization in dogs to improve visual outcome.

Aim: To investigate the pigment epithelium-derived factor (PEDF) concentration in equine amniotic membrane homogenate (EAMH) and its vascular endothelial growth factor (VEGF) inhibition in tears of dogs with vascularized ulcerative keratitis.

Tear production, intraocular pressure, and central corneal thickness in white-tailed deer (Odocoileus virginianus).

Objective: To evaluate the tear production, intraocular pressure, and central corneal thickness in healthy white-tailed deer (Odocoileus virginianus) and assess for seasonal variability.

Animals Studied: Nineteen healthy fawns (3-10 days old) and 8 healthy adult white-tailed deer (164-280 days old) were studied.

Procedures: All fawns were manually restrained for the study, while adult animals were immobilized with an intramuscular injection of combined xylazine (2.