Oral Surg Oral Med Oral Pathol Oral Radiol Endod
January 2007
Objective: The objective of this study was to assess the efficiency of topical applications of podophyllin resin (25%) (P) versus podophyllin resin (25%) together with acyclovir cream (5%) (PA) in the treatment of oral hairy leukoplakia (OHL) in accordance with the following criteria: (1) number of applications necessary for the total clinical resolution of OHL; (2) correlation between the decrease of lesion size and the number of applications; (3) total clinical resolution of OHL; and (4) clinical reevaluation 12 months after the end of treatment.
Study Design: Forty-six OHLs were treated with P (P group) or with PA (PA group). Applications were performed weekly.