Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet.

Introduction: A sedentary lifestyle and high-fat feeding are risk factors for cardiometabolic disorders. This study determined whether moderate exercise training prevents the cardiometabolic changes induced by a high-fat diet (HFD).

Materials And Methods: Sixty-day-old rats were subjected to moderate exercise three times a week for 30 days.

Early overfeed-induced obesity leads to brown adipose tissue hypoactivity in rats.

Background/aims: Brown adipose tissue activation has been considered a potential anti-obesity mechanism because it is able to expend energy through thermogenesis. In contrast, white adipose tissue stores energy, contributing to obesity. We investigated whether the early programming of obesity by overfeeding during lactation changes structure of interscapular brown adipose tissue in adulthood and its effects on thermogenesis.