Efficacy of high-dose vitamin D in pediatric asthma: a systematic review and meta-analysis.

Context: Observational studies have suggested a relationship between vitamin D status and asthma-related respiratory outcomes. The benefit of vitamin D supplementation for pulmonary function, symptoms and exacerbations is not well established.

Objective: To systematically review paediatric clinical trials investigating the role of vitamin D on asthma-related respiratory outcomes.