Publications by authors named "Tatiana Yu Postnikova"
Prenatal hypoxia is a widespread condition that causes various disturbances in later life, including aberrant central nervous system development, abnormalities in EEG rhythms, and susceptibility to seizures. Hypoxia in rats on the 14th day of embryogenesis (E14) disrupts cortical neuroblast radial migration, mainly affecting the progenitors of cortical glutamatergic neurons but not GABAergic interneurons or hippocampal neurons. Thus, hypoxia at this time point might affect the development of the neocortex to a greater extent than the hippocampus.
View Article and Find Full Text PDFArticle Synopsis
- mGluRs, particularly mGluR5, are important in brain signaling and could be targets for brain disease treatments, but their exact role in seizures is unclear.
- The study tested the mGluR5 antagonist MTEP in a rat model of epilepsy and found it did not improve survival or prevent epilepsy development.
- MTEP did prevent neuronal loss and reduce astrogliosis, potentially hinting at a neuroprotective effect, but it didn't alleviate behavioral issues associated with epilepsy, showing its limited effectiveness.