Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men.

Objective: To study and establish sex hormone cutoff levels for osteoporosis risk in men over 50 years old.

Methods: Case-control study of 216 men > 50 years, 110 with osteoporosis (O) and 106 with normal bone density (C). We measured estradiol (E2), sex hormone binding globulin (SHBG), total testosterone (TT) and albumin.