A murine model to evaluate the immunomodulatory properties of proteins.

immunomodulatory vaccine (PiV) has been tested in clinical and experimental pythiosis. Previous data showed that immunogens have the ability to switch the Th2 immune response, normally in place during pythiosis, to a curative Th1 response. Pythiosis cannot be reproduced in experimental rodents with the exception of rabbits, and thus thorough evaluation of PiV´s immunomodulatory properties has been limited by the lack of a compatible inbred mouse model.