Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men.

Objective: To study and establish sex hormone cutoff levels for osteoporosis risk in men over 50 years old.

Methods: Case-control study of 216 men > 50 years, 110 with osteoporosis (O) and 106 with normal bone density (C). We measured estradiol (E2), sex hormone binding globulin (SHBG), total testosterone (TT) and albumin.

Use of vascular Doppler ultrasound to detect acute estradiol vascular effect in postmenopausal women.

Objectives: To report on a simple practical test for assessing acute estradiol vascular effects on healthy and unhealthy postmenopausal women.

Introduction: Estradiol acts in the endothelium to promote vasodilatation through genomic and non-genomic mechanisms, but its vascular action may be impaired in diabetes mellitus, hypertension, smoking and obesity.

Methods: Nineteen postmenopausal women (nine healthy and 10 with two or more of the above factors) of similar age and time since menopause were examined with vascular Doppler ultrasound.

Triplet pregnancy after metformin in a woman with polycystic ovary syndrome.

Objective: To report a case of triplet pregnancy after metformin treatment only, in a woman with polycystic ovary syndrome (PCOS) and a family history of twin pregnancies.

Design: Case report and literature review.

Setting: Gynecologic endocrinology clinic, tertiary federal hospital.