Publications by authors named "Tatiana Knox"
Article Synopsis
- NUT carcinoma (NC) is a rare and aggressive cancer linked to the BRD4-NUTM1 fusion, which currently has no effective treatment options.
- Researchers identified histone deacetylase (HDAC) inhibitors, specifically panobinostat and a new compound IRBM6, as potential treatments that inhibit NUT's transcriptional activity, repress cancer cell growth, and induce differentiation.
- The study indicates that these HDAC inhibitors alter gene expression related to cancer growth and differentiation and show promise in preclinical models for improving treatment outcomes in NC patients.
Article Synopsis
- - NUT midline carcinoma (NMC) is a rare, aggressive cancer linked to the BRD4-NUT fusion oncoprotein, which enhances cancer-related gene expression through its interaction with the p300 protein.
- - Research shows that using inhibitors for both p300/CBP and BET bromodomains together (like GNE-781 and OTX015) effectively reduces levels of the MYC protein and hinders the growth of NMC cells more than using either inhibitor alone.
- - A new dual inhibitor, NEO2734, not only significantly slows tumor growth in NMC but also enhances patient survival in experimental models, suggesting a promising avenue for future clinical studies targeting this cancer.
Nuclear protein of the testis (NUT) midline carcinoma (NMC), is a rare and highly aggressive form of undifferentiated squamous cell carcinoma. NMC is molecularly characterized by chromosomal rearrangement of the NUT gene to another gene, most commonly the bromodomain and extraterminal domain (BET) gene BRD4, forming the BRD4-NUT fusion oncogene. Therefore, inhibiting BRD4-NUT oncogenic function directly by BET inhibitors represents an attractive therapeutic approach but toxicity may limit the use of pan-BET inhibitors treating this cancer.
View Article and Find Full Text PDFHuman and animal studies suggest that both traumatic nerve injury and toxic challenge with chemotherapeutic agents involves the reorganization of neural circuits in the brain. However, there have been no prospective studies, human or animal, using magnetic resonance imaging (MRI) to identify changes in brain neural circuitry that accompany the development of chemotherapy-induced neuropathic pain (i.e.
View Article and Find Full Text PDFParkinson's Disease (PD) is the second most common neurodegenerative disorder, with 60,000 new cases diagnosed each year in the US. There are multiple animal models of PD that attempt to mimic the effects of the disease through genetic alteration. Combined with advanced imaging techniques, these animal models are critical in tracking the neurobiological and behavioral aspects of disease progression and identifying early biomarkers of PD.
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