- Peritonitis can lead to sepsis, a severe inflammatory condition, and this study investigates the role of Granzyme A (GzmA), a protein produced by immune cells, in this process and its potential as a therapeutic target.
- The research involved analyzing GzmA levels in patients with peritonitis and using mice models to study the effects of GzmA deficiency and inhibition on survival and inflammation during sepsis.
- The results showed that higher GzmA levels are linked to worse outcomes in patients and that inhibiting GzmA in mice led to improved survival rates, suggesting GzmA contributes to inflammatory responses but does not affect bacterial control.