Publications by authors named "Tatiana Jakovleva"
Article Synopsis
- The study explored how the timing of starting an obesogenic diet (Cafeteria Diet) affects obesity traits in male and female mice, focusing on pre-puberty and post-puberty initiation.
- Male mice that started the diet before puberty displayed better metabolic health with lower body weight and improved fat metabolism compared to those starting after puberty.
- Conversely, female mice starting the diet before puberty showed poorer metabolic profiles, including higher triglycerides and lower insulin sensitivity, showcasing gender differences in diet impact on obesity development.
Article Synopsis
- FGF21 shows potential as a treatment for obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD), but its effects vary between male and female mice with mutations impacting melanocortin receptors.
- A study found that female mice had higher obesity rates and different metabolic responses compared to males after FGF21 treatment, indicating sex plays a role in how FGF21 affects metabolism.
- While FGF21 increased food intake and activity in both sexes, it only improved metabolic issues like hyperinsulinemia and liver fat in male mice, suggesting the treatment's benefits are more significant for males.
Article Synopsis
- * Female mice showed a stronger preference for high-fat diets, less body fat, and more favorable blood parameters than males, indicating potential sex-based differences in obesity development.
- * FGF21 treatment reduced fat accumulation and improved metabolic markers in both sexes, but it specifically induced beneficial gene expression changes in the female mice's white adipose tissue.
Fasting is often used for obesity correction but the "refeeding syndrome" limits its efficiency, and molecular mechanisms underlying metabolic response to different food availability are under investigation. Sex was shown to affect hormonal and metabolic reactions to fasting/refeeding. The aim of this study was to evaluate hormonal and transcriptional responses to fasting and refeeding in male and female C57Bl/6J mice.
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