Porous Carbon-Carbon Composite Materials Obtained by Alkaline Dehydrochlorination of Polyvinyl Chloride.

Porous carbon-carbon composite materials (PCCCM) were synthesized by the alkaline dehydrochlorination of polyvinyl chloride solutions in dimethyl sulfoxide containing the modifying additives of a nanostructured component (NC): graphite oxide (GO), reduced graphite oxide (RGO) or nanoglobular carbon (NGC), with subsequent two-step thermal treatment of the obtained polyvinylene-NC composites (carbonization at 400 °C and carbon dioxide activation at 900 °C). The focus of the study was on the analysis and digital processing of transmission electron microscopy images to study local areas of carbon composite materials, as well as to determine the distances between graphene layers. TEM and low-temperature nitrogen adsorption studies revealed that the structure of the synthesized PCCCM can be considered as a porous carbon matrix in which either carbon nanoglobules (in the case of NGC) or carbon particles with the "crumpled sheet" morphology (in the case of GO or RGO used as the modifying additives) are distributed.

Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primates.

Although unprecedented efforts aiming to stop the COVID-19 pandemic have been made over the past two years, SARSCoV-2 virus still continues to cause intolerable health and economical losses. Vaccines are considered the most effective way to prevent infectious diseases, which has been reaffirmed for COVID-19. However, in the context of the continuing virus spread because of insufficient vaccination coverage and emergence of new variants of concern, there is a high demand for vaccination strategy amendment.

Immunization with recombinant ORF2 p551 protein protects common marmosets (Callithrix jacchus) against homologous and heterologous hepatitis E virus challenge.

Background: Hepatitis E virus (HEV) is a major causative agent of acute hepatitis worldwide, prompting continuous HEV vaccine efforts. Vaccine development is hampered by the lack of convenient animal models susceptible to infection with different HEV genotypes. We produced recombinant open reading frame 2 protein (pORF2; p551) of HEV genotype (GT) 3 and assessed its immunogenicity and protectivity against HEV challenge in common marmosets (Callithrix jacchus, CM).

Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies.

The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world. Despite the multitude of high-quality papers describing clinical trials of different vaccine products, basic detailed data on general toxicity, reproductive toxicity, immunogenicity, protective efficacy and durability of immune response in animal models are scarce. Here, we developed a β-propiolactone-inactivated whole virion vaccine CoviVac and assessed its safety, protective efficacy, immunogenicity and stability of the immune response in rodents and non-human primates.