Publications by authors named "Tatiana G Shumilina"
Int J Mol Sci
November 2024
Article Synopsis
- * The study aims to identify the positions of intragenic and extragenic Pol III promoters regulating tRNA transcription by examining the DNA properties in the flanking regions of tRNA genes across different organisms, including eukaryotes and archaea.
- * Findings reveal that, while the consensus sequences of A- and B-boxes are similar across all organisms studied, the structural and mechanical properties of DNA in the flanking regions show significant variability both within
Article Synopsis
- - RNA polymerase II (POL II) plays a key role in transcribing both mRNAs and lncRNAs, with structural features of their core promoters showing similarities and differences.
- - Analysis of core promoters for lncRNAs reveals a complex 3D structure, including significant regions like the "INR" near the transcription start site (TSS) and the "TATA-box" further upstream.
- - Textual analysis indicates that lncRNA core promoters have higher informational entropy and a lower occurrence of consensus TATA box sequences compared to mRNA promoters, potentially affecting transcription efficiency.
