Publications by authors named "Tatiana F Otten"
Infection with atypical mycobacteria (MAC) is a well-known complication of AIDS that typically occurs only in people with advanced immunodeficiency. We studied tissues from 13 patients with HIV and atypical mycobacterial infection who died in St Petersburg Russia from 2009-2012. Three patterns of disease were identified that suggest effects of host resistance.
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- The study focuses on the Mycobacterium tuberculosis (MTB) Beijing family, specifically the B0/W148 group found in Russia, which is known for being widespread, hypervirulent, and drug-resistant.
- Researchers sequenced four clinical isolates from this group and compared their genomes to the W-148 strain to identify significant genomic features.
- They discovered two large genomic inversions in the B0/W148 strains, suggesting that such rearrangements in MTB are more common than previously thought, highlighting the need for further research into these genetic changes.