Axially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migration.

The metallodrug chloridotetrakis(ibuprofenato)diruthenium(II,III) ([Ru(Ibp)Cl] or RuIbpCl (1), Ibp=carboxylate anion derived from the non-steroidal anti-inflammatory drug ibuprofen) has shown promising results in vitro and in vivo, which point to its potential as an inhibitor of glioma tumour growth in vivo. In order to get insight into the influence of structural changes on the biological response of the metallodrug, the [Ru(Ibp)] metal-metal multiply bonded paddlewheel unit was modified for the axial ligand. Two new analogues, [Ru(Ibp)(CFSO)] (2) and [Ru(Ibp)(EtOH)]PF (3), were synthesized and fully characterized by elemental analysis, ESI-MS, vibrational (FTIR, Raman) and electronic (UV/VIS/NIR) spectroscopy, magnetic susceptibility, molar conductivity measurements, and thermal analysis.

Mycotoxins detection by chromatography.

Mycotoxins are metabolites and toxic substances produced by certain filamentous fungi that frequently contaminate food and agriculture commodities and it may cause disease in animals or humans. The toxigenic fungi are responsible for mycotoxin production in food that belongs to mainly three genera: Aspergillus, Penicillium and Fusarium. The contamination of food by mycotoxins is difficult to control in addition, causing economic impacts on public health, so their identification and quantifications are very necessary.